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Titolo:
Cilostazol, a phosphodiesterase inhibitor, improves insulin sensitivity inthe Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous NIDDM
Autore:
Nakaya, Y; Minami, A; Sakamoto, S; Niwa, Y; Ohnaka, M; Harada, N; Nakamura, T;
Indirizzi:
Univ Tokushima, Sch Med, Dept Nutr, Tokushima, Japan Univ Tokushima Tokushima Japan ma, Sch Med, Dept Nutr, Tokushima, Japan
Titolo Testata:
DIABETES OBESITY & METABOLISM
fascicolo: 1, volume: 1, anno: 1999,
pagine: 37 - 41
SICI:
1462-8902(199901)1:1<37:CAPIII>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; LIPID-METABOLISM; BLOOD-FLOW; GLUCOSE; HYPERTENSION; RESISTANCE; SECRETION; LEPTIN;
Keywords:
Otsuka Long-Evans Tokushima Fatty rat; cilostazol; insulin-sensitivity; non-insulin dependent diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Nakaya, Y Univ Tokushima, Sch Med, Dept Nutr, 3-18-15 Kuramoto Cho, Tokushima, Japan Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japan ima, Japan
Citazione:
Y. Nakaya et al., "Cilostazol, a phosphodiesterase inhibitor, improves insulin sensitivity inthe Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous NIDDM", DIABET OB M, 1(1), 1999, pp. 37-41

Abstract

Aim: Angiotensin converting enzyme inhibitors and alpha(1)-adrenergic blockers improve insulin sensitivity, the mechanism of which was considered, atleast in part, to be due to the increased blood flow to muscle. The present study aimed to clarify whether cilostazol, a phosphodiesterase inhibitor,improves insulin sensitivity in a model of spontaneous non-insulin dependent diabetes mellitus (NIDDM), Otsuka Long-Evans Tokushima Fatty (OLETF) rat. Methods: OLETF rats were divided into the two groups at the age of 16 weeks: the cilostazol-supplemented group (cilostazol 40 mg/kg/day) and the normal-diet group. As a non-diabetic control, we used Long-Evans-Tokushima-Otsuka rats (non-diabetic rats). Oral glucose tolerance test and hyperinsulinemic euglycemic clamp was performed at the ages of 23 and 25 weeks, respectively. Serum levels of lipids and leptin were measured. Results: Body weight and abdominal fat was increased in OLETF rats but cilostazol supplementation did not alter them. Insulin sensitivity, as measured by the hyperinsulinemic euglycemic clamp technique, was significantly decreased in OLETF rats (glucose infusion rate: 73.5 +/- 10.0 vs. 41.5 +/- 9.8mu mol/min/kg body weight, p < 0.01). Cilostazol supplementation improved insulin sensitivity partially but significantly 51.0 +/- 5.7 mu mol/min/kg body weight, p < 0.05) in OLETF rats at 25 weeks of age, although it did not decrease serum levels of glucose, lipids or leptin. However, this effect was not observed in non-diabetic rats. Conclusion: Cilostazol, which is used in diabetic patients for the treatment of obstructive disease of artery, is expected to have a beneficial effect on insulin sensitivity in NIDDM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 05:40:03