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Titolo:
Demarcation of early mammalian cortical development by differential expression of fringe genes
Autore:
Ishii, Y; Nakamura, S; Osumi, N;
Indirizzi:
Natl Inst Neurosci, Div Biochem & Cellular Biol, Kodaira, Tokyo 1878502, Japan Natl Inst Neurosci Kodaira Tokyo Japan 1878502 aira, Tokyo 1878502, Japan Tohoku Univ, Grad Sch Med, Dept Dev Neurobiol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 119, anno: 2000,
pagine: 307 - 320
SICI:
0165-3806(20000207)119:2<307:DOEMCD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-CORTEX; LUNATIC FRINGE; SEMITHIN SECTIONS; CORPUS-CALLOSUM; DELTA-HOMOLOG; GLIAL CELLS; YOUNG-RATS; NOTCH; NEUROGENESIS; CHICK;
Keywords:
fringe; mouse; cerebral cortex; neurogenesis; cell division; subventricular zone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Osumi, N Natl Inst Neurosci, Div Biochem & Cellular Biol, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878502, Japan Natl Inst Neurosci 4-1-1 Ogawa Higashi Kodaira Tokyo Japan 1878502
Citazione:
Y. Ishii et al., "Demarcation of early mammalian cortical development by differential expression of fringe genes", DEV BRAIN R, 119(2), 2000, pp. 307-320

Abstract

Fringe has originally been found in Drosophila as a gene encoding a putative secreted protein which regulates the sensitivity of Notch signaling pathway to different ligands. We show that three members of murine fringe gene family, Lunatic fringe (L-fng), Manic fringe (M-fng) and Radical fringe (R-fng), show related patterns of expression in the developing cerebral wall. L-fng is expressed in immature cells in the ventricular zone. M-fng is upregulated transiently in maturing neurons when they leave the ventricular zone (VZ). R-fng is upregulated in more mature neurons when they enter the preplate and cortical plate. These patterns suggest that the transition from immature to mature neurons involves sequential changes in the member of fringe family genes expressed. More detailed expression analyses of fringe genes and immunohistochemistry for neuron-specific class III beta-tubulin suggest a mode of neurogenesis which might underlie the histogenesis of the cerebral cortex. A proliferative population situated outside of the VZ is defined as M-fng-positive/BrdU-positive cells, which constitutes about 10-20% ofthe total S-phase cells in the cerebral wall of embryonic day 10.5-12.5. We found that M-fng is expressed in mitotic figures outside the VZ and some of them react with the antibody against class III P-tubulin. These observations suggest that a significant number of proliferative cells exist outsidethe VZ, which supply neurons during early cortical development. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 22:42:16