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Titolo:
Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systems
Autore:
Pletnikov, MV; Rubin, SA; Schwartz, GJ; Carbone, KM; Moran, TH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 av Sci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 pt Med, Baltimore, MD 21205 USA US FDA, CBER, Lab Pediat & Resp Viral Dis, Bethesda, MD 20892 USA US FDA Bethesda MD USA 20892 iat & Resp Viral Dis, Bethesda, MD 20892 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 119, anno: 2000,
pagine: 179 - 185
SICI:
0165-3806(20000207)119:2<179:EONRBD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYLAZOXYMETHANOL ACETATE; ELECTROCHEMICAL DETECTION; FRONTAL-CORTEX; NEUROCHEMISTRY; ABNORMALITIES; MALNUTRITION; RECEPTORS; NEOCORTEX; ONTOGENY; MARKERS;
Keywords:
Borna; development; monoamine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Pletnikov, MV Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Ross618,720 Rutland Ave, Baltimore, MD 21205 USA Johns Hopkins Univ Ross 618,720 Rutland Ave Baltimore MD USA 21205
Citazione:
M.V. Pletnikov et al., "Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systems", DEV BRAIN R, 119(2), 2000, pp. 179-185

Abstract

Effects of neonatal Borna disease virus infection (BDV) on the postnatal development of brain monoaminergic systems in rats were studied. Tissue content of norepinephrine (NE), dopamine (DA) and its metabolite, 3,4-dihydroxyphenol acetic acid (DOPAC), and serotonin (5-HT) and its metabolite, 5-hydroxyindole-3-acetic acid (5-HIAA) were assayed by means of HPLC-EC in frontal cortex, cerebellum, hippocampus, hypothalamus and striatum of neonatally BDV-infected and sham-inoculated male Lewis rats of 8, 14, 21, 60 and 90 days of age. Both NE and 5-HT concentrations were significantly affected by neonatal BDV infection. The cortical and cerebellar levels of NE and 5-HT were significantly greater in BDV-infected rats than control animals at postnatal days (PND) 60 and 90. Tissue content of NE in hippocampus was unaffected. In hippocampus, neonatally BDV-infected rats had lower 5-HT levels at PND 8 and significantly elevated levels at PND 21 and onwards. Neither striatal levels of 5-HT nor hypothalamic levels of 5-HT and NE were affected by neonatal BDV infection, suggesting that the monoamine systems in the prenatally maturing brain regions are less sensitive to effects of neonatal viralinfection. 5-HIAA/5-HT ratio was not altered in BDV-infected rats indicating no changes in the 5-HT turnover in the brain regions damaged by the virus. Neither DA nor DOPAC/DA ratio was affected by neonatal BDV infection in any of the brain regions examined. The present data demonstrate significantand specific alterations in monoaminergic systems in neonatally BDV-infected rats. This pattern of changes is consistent with the previously reportedbehavioral abnormalities resulting from neonatal BDV infection. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/04/20 alle ore 00:46:03