Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
Autore:
Galceran, J; Miyashita-Lin, EM; Devaney, E; Rubenstein, JLR; Grosschedl, R;
Indirizzi:
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Microbiol, San Francisco, CA 94143 USA UnivCalif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 3, volume: 127, anno: 2000,
pagine: 469 - 482
SICI:
0950-1991(200002)127:3<469:HDAGOD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR LEF-1; BETA-CATENIN; HMG-BOX; NUCLEAR-LOCALIZATION; INT-1 PROTOONCOGENE; WINGLESS PROTEIN; XENOPUS EMBRYOS; HOMEOBOX GENE; NEURAL CREST; SPINAL-CORD;
Keywords:
LEF1/TCF hippocampus; dentate gyrus; granule cells; Wnt;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Grosschedl, R Univ Munich, Gene Ctr, Feodor Lynenstr 25, D-81377 Munich, Germany Univ Munich Feodor Lynenstr 25 Munich Germany D-81377 rmany
Citazione:
J. Galceran et al., "Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1", DEVELOPMENT, 127(3), 2000, pp. 469-482

Abstract

Lef1 and other genes of the LEF1/TCF family of transcription factors are nuclear mediators of Wnt signaling. Here we examine the expression pattern and functional importance of Lef1 in the developing forebrain of the mouse. Lef1 is expressed in the developing hippocampus, and LEF1-deficient embryoslack dentate gyrus granule cells but contain glial cells and interneurons in the region of the dentate gyrus. In mouse embryos homozygous for a Lef1-lacZ fusion gene, which encodes a protein that is not only deficient in DNAbinding but also interferes with beta-catenin-mediated transcriptional activation by other LEF1/TCF proteins, the entire hippocampus including the CAfields is missing. Thus, LEF1 regulates the generation of dentate gyrus granule cells, and together with other LEF1/TCF proteins, the development of the hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:42:31