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Titolo:
UROCORTIN, A NOVEL NEUROPEPTIDE WITH ANXIOGENIC-LIKE PROPERTIES
Autore:
MOREAU JL; KILPATRICK G; JENCK F;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,DIV PHARMA,PRECLIN CNS RES CH-4070 BASELSWITZERLAND
Titolo Testata:
NeuroReport
fascicolo: 7, volume: 8, anno: 1997,
pagine: 1697 - 1701
SICI:
0959-4965(1997)8:7<1697:UANNWA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; ETHANOL WITHDRAWAL; FACTOR ANTAGONIST; ANXIETY; CHLORDIAZEPOXIDE; RATS; BEHAVIOR; REVERSES; NOVELTY; CRH;
Keywords:
ANXIETY; CORTICOTROPIN-RELEASING FACTOR (CRF); CRF2 RECEPTOR; STRESS; UROCORTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Moreau et al., "UROCORTIN, A NOVEL NEUROPEPTIDE WITH ANXIOGENIC-LIKE PROPERTIES", NeuroReport, 8(7), 1997, pp. 1697-1701

Abstract

POTENTIAL anxiogenic-like properties of urocortin, a corticotropin-releasing factor (CRF)-related neuropeptide, were investigated in modelsof anxiety in rodents. In the elevated plus-maze, CRF- and urocortin-treated rats (0.1 nmol, i.c.v.) spent less time and made fewer entriesinto open arms. In the light-dark test in mice, urocortin (0.006-0.06nmol, i.c.v.) dose-dependently reduced time and number of transitionsinto the lit area. Urocortin also dose-dependently (0.02-0.2 nmol, i.c.v.:) reduced mice exploratory behaviour in an open field. This effect was reversed by diazepam (0.1-1 mg/kg, i.p) and by the CRF receptor antagonist cw-helical CRF (0.8-8 nmole, i.c.v.). These data show that urocortin produces anxiety-like effects in several behavioural paradigms in rodents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 15:07:45