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Titolo:
Effects of insulin on the cardiac autonomic nervous system in insulin-resistant states
Autore:
Paolisso, G; Manzella, D; Rizzo, MR; Barbieri, M; Varricchio, G; Gambardella, A; Varricchio, M;
Indirizzi:
Univ Naples 2, Dept Geriatr Med & Metab Dis, Serv Astanteria Med, I-80138 Naples, Italy Univ Naples 2 Naples Italy I-80138 Astanteria Med, I-80138 Naples, Italy
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 2, volume: 98, anno: 2000,
pagine: 129 - 136
SICI:
0143-5221(200002)98:2<129:EOIOTC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPECTRAL-ANALYSIS; SENSITIVITY; PHYSIOLOGY; HUMANS; INDEX;
Keywords:
cardiac autonomic nervous system; heart rate variability; insulin resistance; leg blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Paolisso, G Univ Naples 2, Dept Geriatr Med & Metab Dis, Serv Astanteria Med, Piazza Miraglia 2, I-80138 Naples, Italy Univ Naples 2 Piazza Miraglia 2 Naples Italy I-80138 s, Italy
Citazione:
G. Paolisso et al., "Effects of insulin on the cardiac autonomic nervous system in insulin-resistant states", CLIN SCI, 98(2), 2000, pp. 129-136

Abstract

The effects of insulin infusion on cardiac autonomic nervous system (ANS) activity were investigated in healthy subjects (n = 15) and in patients with various types of insulin-resistance, such as obese subjects (n = 20) and those with hypertension (n = 15) or type II (non-insulin-dependent) diabetes (n = 22). Healthy subjects and patients underwent euglycaemic hyperinsulinaemic glucose clamp, and cardiac ANS and haemodynamic changes were investigated by continuous recording of heart rate variability by the Holter technique and by venous occlusion plethysmography respectively. At baseline, healthy subjects had the highest values for total spectral power and the low-frequency (LF) component, and the lowest value for the high-frequency (HF) component. In the pooled data (n = 72), the fasting plasma insulin concentration was correlated with baseline total spectral power (r = -0.37; P < 0.001) and the LF/HF ratio (r = -0.35; P < 0.003). Such correlations were stillsignificant (P < 0.01 for both) after adjustment for body fat and mean arterial blood pressure. In a multivariate linear stepwise analysis (n = 72), a model including body fat, waist/hip ratio, fasting plasma glucose concentration and insulin-mediated glucose uptake explained 47% of the variabilityof the change in the LF/HF ratio, with body fat (t = -3.11; P < 0.01) and insulin-mediated glucose uptake (t = -3.48; P < 0.008) being significantly and independently associated with insulin-mediated changes in the LF/HF ratio. Insulin infusion reduced the total spectral power and increased the LF/HF ratio in healthy subjects, but not in insulin-resistant patients. In conclusion, our study demonstrates that insulin fails to stimulate cardiac ANSactivity in insulin-resistant patients, independently of the causes of insulin resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:32:49