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Titolo:
Joint cartilage repair with transplantation of embryonic chondrocytes embedded in collagen-fibrin matrices
Autore:
Perka, C; Schultz, O; Lindenhayn, K; Spitzer, RS; Muschik, M; Sittinger, M; Burmester, GR;
Indirizzi:
Humboldt Univ, Charite Univ Hosp, Dept Orthoped, Berlin, Germany Humboldt Univ Berlin Germany Univ Hosp, Dept Orthoped, Berlin, Germany Humboldt Univ, Charite Univ Hosp, Dept Rheumatol & Clin Immunol, Berlin, Germany Humboldt Univ Berlin Germany Rheumatol & Clin Immunol, Berlin, Germany
Titolo Testata:
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
fascicolo: 1, volume: 18, anno: 2000,
pagine: 13 - 22
SICI:
0392-856X(200001/02)18:1<13:JCRWTO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTICULAR-CARTILAGE; OSTEOPERIOSTEAL GRAFTS; ALLOGRAFT CHONDROCYTES; IN-VITRO; DEFECTS; CULTURE; RABBIT; SURFACES; KNEE; BONE;
Keywords:
chondrocyte transplantation; cartilage repair; cell transplantation methods;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Schultz, O Charite, Med Klin 3, Schumannstr 20-21, D-10098 Berlin, GermanyCharite Schumannstr 20-21 Berlin Germany D-10098 rlin, Germany
Citazione:
C. Perka et al., "Joint cartilage repair with transplantation of embryonic chondrocytes embedded in collagen-fibrin matrices", CLIN EXP RH, 18(1), 2000, pp. 13-22

Abstract

Objective The objective of this study was to assess the feasibility of transplanting embryonic chondrogenic cells within a collagen-fibrin substrate for the reconstitution of full-thickness cartilage defects in chicken knee joints. Methods Full-thickness cartilage defects were created mechanically on the weight-bearing surface of the tibial condyle in 45 adult chickens and subsequently filled with chondrocytes embedded in a chondrocyte-collagen-fibrin gel. The transplants were compared to untreated defects and collagen-fibrintransplants without cells. The results were analyzed using histochemical and morphometrical methods after 3, 12 and 24 weeks. A semiquantitative histological grading system was applied to evaluate the transplant integration and the newly formed cartilage architecture. Results Chondrocyte-gel grafts developed to hyaline-like cartilage withoutant. granulation tissue in the interface after 3 weeks. After 12 weeks thedefects in the experimental group were filled completely with hyaline cartilage. The defects in the central groups in all cases healed with fibrous repair tissue. Conclusion Fibrin-collagen gel allowed stable graft fixation and provided art adequate microenvironment for embryonic chondrocytes to generate hyaline-like neocartilage irt a fill-thickness cartilage defect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:35:09