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Titolo:
Comparison of clinical and immunogenetic features in familial versus sporadic psoriatic arthritis
Autore:
Rahman, P; Schentag, CT; Beaton, M; Gladman, DD;
Indirizzi:
Univ Toronto, Toronto Hosp, Western Div,Ctr Prognosis Studies Rheumat Dis,Div Rheumatol,Psoriat Arthrit Clin, Toronto, ON MST 2S8, Canada Univ Toronto Toronto ON Canada MST 2S8 Clin, Toronto, ON MST 2S8, Canada
Titolo Testata:
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
fascicolo: 1, volume: 18, anno: 2000,
pagine: 7 - 12
SICI:
0392-856X(200001/02)18:1<7:COCAIF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA ANTIGENS; RHEUMATOID-ARTHRITIS; GENETICS; DISEASE;
Keywords:
psoriatic arthritis; familial; sporadic; immunogenetics; age at onset;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Gladman, DD Univ Toronto, Toronto Hosp, Western Div,Ctr Prognosis Studies Rheumat Dis,Div Rheumatol,Psoriat Arthrit Clin, 1-318 Main Pavil,399 Bathurst St, Toronto, ON MST 2S8, Canada Univ Toronto 1-318 Main Pavil,399 Bathurst St Toronto ON Canada MST 2S8
Citazione:
P. Rahman et al., "Comparison of clinical and immunogenetic features in familial versus sporadic psoriatic arthritis", CLIN EXP RH, 18(1), 2000, pp. 7-12

Abstract

Objective To compare patients with familial versus sporadic psoriatic arthritis (PsA) with respect to clinical, radiological and immunogenetic features. Methods All patients were identified from the University of Tor-onto Psoriatic Arthritis Clinic. Familial and sporadic PsA were distinguished based on the proband's self-reported history. The probands were compared at presentation to clinic with respect to demographic information age of onset of psoriasis and inflammatory arthritis, disease activity disease damage, laboratory variables, functional class and HLA antigens. The two groups were compared rising a univariate analysis. Results In total 407 patients were included. Thirty-six patients (8.8%) were eliminated as they reported a family history of arthritis in the absenceof psoriasis. Of the remaining 371 patients, 150 patients reported a positive family of either PsA or psoriasis. 221 patients (54.2%) had no family history of psoriatic arthritis, psoriasis, or "arthritis". The familial group were younger. at presentation to clinic (p = 0.003), had an earlier age of onset of psoriasis (p = 0.001) and inflammatory arthritis (p = 0.001) andwere more likely to be receiving treatment (p = 0.001). The mean number ofactively inflamed joints was higher in the sporadic group (p = 0.035), along with a higher frequency of rheumatoid factor positivity (p = 0.04). Onlythe age of onset variables and medication use retained significance after correction for multiple comparisons. Conclusions In comparing probands with familial versus sporadic PsA, we noted a marked difference in the age of onset of psoriasis and inflammatory arthritis, along with other differences ill several clinical variables. These differences may be helpful in identifying PsA patients with a stronger genetic predisposition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 07:12:43