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Titolo:
Cytologic differential diagnosis among reactive mesothelial cells, malignant mesothelioma, and adenocarcinoma - Utility of combined E-cadherin and calretinin immunostaining
Autore:
Kitazume, H; Kitamura, K; Mukai, K; Inayama, Y; Kawano, N; Nakamura, N; Sano, J; Mitsui, K; Yoshida, S; Nakatani, Y;
Indirizzi:
Yokohama City Univ Hosp, Sch Med, Div Anat & Surg Pathol, Kanazawa Ku, Yokohama, Kanagawa 2368566, Japan Yokohama City Univ Hosp Yokohama Kanagawa Japan 2368566 wa 2368566, Japan Yokohama Citizens Hosp, Dept Pathol, Yokohama, Kanagawa, Japan Yokohama Citizens Hosp Yokohama Kanagawa Japan Yokohama, Kanagawa, Japan Yokohama Kowan Hosp, Dept Pathol, Yokohama, Kanagawa, Japan Yokohama KowanHosp Yokohama Kanagawa Japan l, Yokohama, Kanagawa, Japan
Titolo Testata:
CANCER CYTOPATHOLOGY
fascicolo: 1, volume: 90, anno: 2000,
pagine: 55 - 60
SICI:
0008-543X(20000225)90:1<55:CDDARM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL MEMBRANE ANTIGEN; PLEURAL MESOTHELIOMAS; LUNG ADENOCARCINOMAS; N-CADHERIN; EXPRESSION; CARCINOMA; ADHESION; EXPERIENCE; EFFUSIONS; MARKER;
Keywords:
immunostaining; mesothelial cell; mesothelioma; adenocarcinoma; E-cadherin; calretinin; cytologic diagnosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kitazume, H Yokohama City Univ Hosp, Sch Med, Div Anat & Surg Pathol, Kanazawa Ku, 3-9Fukuura, Yokohama, Kanagawa 2368566, Japan Yokohama City Univ Hosp 3-9 Fukuura Yokohama Kanagawa Japan 2368566
Citazione:
H. Kitazume et al., "Cytologic differential diagnosis among reactive mesothelial cells, malignant mesothelioma, and adenocarcinoma - Utility of combined E-cadherin and calretinin immunostaining", CANC CYTOP, 90(1), 2000, pp. 55-60

Abstract

BACKGROUND. The differential diagnosis between reactive mesothelial cells (RMs), malignant mesotheliomas (MMs), and adenocarcinomas (ACs) is often difficult in cytologic specimens, and the utility of various immunohistochemical markers have been explored. Because recent immunohistologic studies have suggested that E-cadherin (E-cad) and calretinin (Cal) may be useful markers for epithelial and mesothelial differentiations, respectively, the authors investigated their utility in cytologic diagnosis. METHODS, In this retrospective study, immunostaining was performed on smears retrieved from Papanicolaou-stained slides of effusions using the labeled streptavidin-biotin method. Sixteen cases of RM, 9 cases of MM, and 52 cases of AC from various sites, including 13 pulmonary primaries, were examined with primary antibodies against E-cad and Gal. RESULTS. The positive rates for E-cad and Gal, respectively, were as follows: RM, 0/16 (0%) and 16/16 (100%); MM, 9/9 (100%) and 8/8 (100%); and AC, 45/52 (86.5%) and 0/51 (0%). The E-cad expression by neoplastic cells was strongest in the intercellular junctions, and poorly differentiated neoplastic cells in the single cell farm showed the weakest expression. CONCLUSIONS. In contrast to the results of previous immunohistochemical studies, the current study indicates that MMs constantly express E-cad, whereas RMs lack its expression in cytologic specimens, which would be useful inthe differential diagnosis between the two. On the other hand, E-cad expression is not reliable for distinguishing AC from MM. The Cal expression canbe a Very useful marker for the distinction between AC and the mesotheliallineage. The combined immunostaining for E-cad and Cat has utility in differential diagnosis among RM, MM, and AC. Cancer (Cancer Cytopathol) 2000;90:55-60, (C) 2000 American Cancer Society.

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Documento generato il 30/11/20 alle ore 16:26:46