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Titolo:
Cytology of thymomas - Emphasis on morphology and correlation with histologic subtypes
Autore:
Chhieng, DC; Rose, D; Ludwig, ME; Zakowski, MF;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Cytol Serv, New York, NY 10016 USA Mem SloanKettering Canc Ctr New York NY USA 10016 New York, NY 10016 USA NYU Med Ctr, Dept Cytol, New York, NY 10016 USA NYU Med Ctr New York NY USA 10016 Ctr, Dept Cytol, New York, NY 10016 USA Hartford Hosp, Dept Pathol, Hartford, CT 06115 USA Hartford Hosp HartfordCT USA 06115 , Dept Pathol, Hartford, CT 06115 USA
Titolo Testata:
CANCER CYTOPATHOLOGY
fascicolo: 1, volume: 90, anno: 2000,
pagine: 24 - 32
SICI:
0008-543X(20000225)90:1<24:COT-EO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINE-NEEDLE ASPIRATION; DIFFERENTIAL-DIAGNOSIS; INVASIVE THYMOMA; FEATURES; TUMORS; BIOPSY;
Keywords:
cytology; thymomas; histologic classification; biologic behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Zakowski, MF Mem Sloan Kettering Canc Ctr, Cytol Serv, 1275 York Ave, New York, NY 10016 USA Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10016
Citazione:
D.C. Chhieng et al., "Cytology of thymomas - Emphasis on morphology and correlation with histologic subtypes", CANC CYTOP, 90(1), 2000, pp. 24-32

Abstract

BACKGROUND. Aspirates of thymomas are distinguishable from other lesions and fine-needle aspiration (FNA) is a proven method for investigating mediastinal masses. METHODS. Thirty-four cytology specimens of thymomas from 31 patients were examined. Corresponding surgical materials were available in 32 cases. Ten cases were benign and 22 were malignant. Cytologic features of these thymomas were correlated with various histologic classification systems and with biologic behavior. Dual epithelial and lymphoid populations and irregular cohesive tissue fragments of varying proportions of lymphoid and epithelial cells were characteristic of all aspirates. RESULTS. Using the Lattes-Bernatz classification, la cases predominately were lymphocytic, 3 cases predominately were epithelial, 3 cases predominately were spindle, 15 cases predominately were mixed, and 1 case was a thymiccarcinoma. In the Muller-Hermelink classification, 3 cases were medullary,12 were mixed, 8 predominately were cortical, 2 were cortical, 6 were welldifferentiated thymic carcinoma, and 1 was a poorly differentiated thymic carcinoma. In the majority of the cases the epithelial cells were round to oval. Spindle cells and a mixture of round to oval and spindle cells also were observed. No cytologic feature was found to correlate significantly with any classification scheme. Necrosis was present in 5 of the 32 aspirates,most frequently in malignant tumors. Thymomas showing predominately spindle cells frequently were encapsulated. Tumors with predominantly round to oval cells or a mixed population behaved more aggressively than those with spindle cells. Tumors that were well encapsulated and benign clinically tended to possess benign-appearing nuclei. Among the 22 invasive or malignant lesions, 8 exhibited moderate to marked cytologic atypia and 14 showed littleor no atypia. No atypia was observed in benign tumors. CONCLUSIONS, The presence of cytologic atypia of epithelial cells map be helpful in predicting aggressiveness. However, the absence of atypia and necrosis may not imply a benign course. Correlation with clinical and radiographic findings should be sought. Cancer (Cancer Cytopathol) 2000;90:24-32. (C) 2000 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:27:27