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Titolo:
Morphologic and electrophysiologic maturation in developing dentate gyrus granule cells
Autore:
Liu, XS; Tilwalli, S; Ye, GL; Lio, PA; Pasternak, JF; Trommer, BL;
Indirizzi:
Evanston NW Healthcare Res Inst, Evanston, IL 60201 USA Evanston NW Healthcare Res Inst Evanston IL USA 60201 nston, IL 60201 USA Evanston Hosp, Dept Pediat, Div Neurol, Evanston, IL 60201 USA Evanston Hosp Evanston IL USA 60201 t, Div Neurol, Evanston, IL 60201 USA Northwestern Univ, Sch Med, Dept Neurol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Neurol, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Dept Pediat, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Pediat, Chicago, IL 60611 USA Northwestern Univ, Inst Neurosci, Chicago, IL 60611 USA Northwestern UnivChicago IL USA 60611 st Neurosci, Chicago, IL 60611 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 856, anno: 2000,
pagine: 202 - 212
SICI:
0006-8993(20000221)856:1-2<202:MAEMID>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-MICROSCOPIC ANALYSIS; POSTNATAL-DEVELOPMENT; MEMBRANE-PROPERTIES; ADULT-RAT; NEURONS; LIGHT; PROLIFERATION; NEUROGENESIS; CURRENTS; ORIGIN;
Keywords:
hippocampus; dentate gyrus; granule cell; development; neuronal maturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Trommer, BL Evanston Hosp, Evanston NW Healthcare, 2650 Ridge Ave, Evanston, IL 60201 USA Evanston Hosp 2650 Ridge Ave Evanston IL USA 60201 L 60201 USA
Citazione:
X.S. Liu et al., "Morphologic and electrophysiologic maturation in developing dentate gyrus granule cells", BRAIN RES, 856(1-2), 2000, pp. 202-212

Abstract

Dentate gyrus granule cells from immature (7-28 days) Sprague-Dawley mts were examined with whole cell patch clamp recordings and biocytin filling inin vitro hippocampal slice preparations. Although recordings were confinedto the middle third of the suprapyramidal limb of the dentate, the granulecells exhibited marked variability in their physiologic properties: input resistance (IR) ranged from 250 M Omega to 3 G Omega, and resting membrane potential (RMP) from -82 to -41 mV. Both IR and RMP were inversely correlated with dendritic length, a morphometric indicator of cell maturity. Thus the highest IR cells were the youngest, and maturation was characterized by a progressive decrease in IR, hyperpolarization of RMP, and elongation of the dendritic arbor. When cells were grouped by IR, significant intergroup differences were found in RMP, dendritic length, and number of dendritic terminal branches. Although cells of all IR categories were examined throughout the age spectrum under study, none of the inter-IR group differences was age-dependent. These data suggest that IR provides a reasonable estimate: of granule cell maturity and that maturation entails predictable changes in cell properties and morphology. These aspects of maturation correlate with each other, are independent of animal age, and most likely proceed according to a program related to cell bir th. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 30/11/20 alle ore 09:50:03