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Titolo:
Synthesis and study of a new adenine-acridine tandem, inhibitor of exonuclease III
Autore:
Belmont, P; Demeunynck, M; Constant, JF; Lhomme, J;
Indirizzi:
Univ Grenoble 1, LEDSS, CNRS, UMR 5616, F-38041 Grenoble 9, France Univ Grenoble 1 Grenoble France 9 , UMR 5616, F-38041 Grenoble 9, France
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 3, volume: 10, anno: 2000,
pagine: 293 - 295
SICI:
0960-894X(20000207)10:3<293:SASOAN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLEAVE APURINIC SITES; DNA-REPAIR; EXCISION-REPAIR; AP LYASES; ENDONUCLEASES; MECHANISMS; EFFICIENT; MOLECULES; RECOGNIZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Demeunynck, M Univ Grenoble 1, LEDSS, CNRS, UMR 5616, BP 53, F-38041 Grenoble 9, France Univ Grenoble 1 BP 53 Grenoble France 9 Grenoble 9, France
Citazione:
P. Belmont et al., "Synthesis and study of a new adenine-acridine tandem, inhibitor of exonuclease III", BIOORG MED, 10(3), 2000, pp. 293-295

Abstract

A new heterodimer adenine-chain-acridine containing a mixed amido-guanidinium linker chain was synthesized. To achieve the synthesis a new method of introduction of aminoalkyl chain at position 9 of adenine was designed. Theheterodimer interacts specifically with the abasic sites in DNA and inhibits the major base excision repair enzyme in Escherichia coli, Exonuclease III. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 08:55:05