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Titolo:
A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression
Autore:
Berman, RM; Narasimhan, M; Sanacora, G; Miano, AP; Hoffman, RE; Hu, XS; Charney, DS; Boutros, NN;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ, Sch Epidemiol & Publ Hlth, New Haven, CT USA Yale Univ New Haven CT USA Sch Epidemiol & Publ Hlth, New Haven, CT USA Connecticut Mental Hlth Ctr, Clin Neurosci Res Unit, New Haven, CT USA Connecticut Mental Hlth Ctr New Haven CT USA Res Unit, New Haven, CT USA VA Connecticut Healthcare Syst, Affect Disorders Program, W Haven, CT USA VA Connecticut Healthcare Syst W Haven CT USA s Program, W Haven, CT USA Yale Psychiat Inst, New Haven, CT USA Yale Psychiat Inst New Haven CT USA ale Psychiat Inst, New Haven, CT USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 47, anno: 2000,
pagine: 332 - 337
SICI:
0006-3223(20000215)47:4<332:ARCTOR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Keywords:
major depression; transcranial magnetic stimulation; randomized clinical trial; medication resistance; neuroanatomy; dorsolateral prefrontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Berman, RM Connecticut Mental Hlth Ctr, Clin Neurosci Unit, Rm 360,34 Pk St, New Haven, CT 06519 USA Connecticut Mental Hlth Ctr Rm 360,34 Pk St New Haven CT USA 06519
Citazione:
R.M. Berman et al., "A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression", BIOL PSYCHI, 47(4), 2000, pp. 332-337

Abstract

Background: Multiple groups have reported on the use of repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant major depression. The purpose of this study is to assess the efficacy of rTMS in unmedicated,treatment-resistant patients who meet criteria for major depression. Methods: Depressed subjects, who had failed to respond to a median of fourtreatment trials, were assigned in a randomized double-blind manner to receive either active (n = 10; 20 2-sec trains of 20 Hz stimulation with 58-sec intervals; delivered at 80% motor threshold with th figure-of-eight coil positioned over the left dorsolateral prefrontal cortex) or sham (n = 10; similar conditions with the coil elevated and angled 45 degrees tangentiallyto the scalp) rTMS. These sequences were applied during 10 consecutive weekdays. Continuous electroencephalogram sampling an daily motor threshold determinations were also obtained. Results: The group mean 25-item Hamilton Depression Rating Scale (HDRS) score was 37.2 (+/- 2.0 SEM) points. Adjusted mean decreases in HDRS scores were 14.0 (+/- 3.7) and 0.2 (+/- 4.1) points for the active and control groups, respectively (p < .05). One of 10 subjects receiving active treatment demonstrated a robust response (i.e., HDRS decreased from 47 to 7 points); three other patients demonstrated 40-45% decreases in HDRS scores. No patients receiving sham treatment demonstrated partial or full responses. Conclusions: a 2-week course of active rTMS resulted in statistically significant but clinically modest reductions of depressive symptoms, as compared to sham rTMS in a population characterized by treatment resistance. Biol Psychiatry 2000;47:332-337 (C) 2000 Society of Biological Psychiatry.

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Documento generato il 18/01/20 alle ore 02:26:13