Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cytoplasmic STAT proteins associate prior to activation
Autore:
Haan, S; Kortylewski, M; Behrmann, I; Muller-Esterl, W; Heinrich, PC; Schaper, F;
Indirizzi:
Rhein Westfal TH Aachen, Inst Biochem, D-52074 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52074 , D-52074 Aachen, Germany Univ Mainz, Dept Physiol Chem & Pathochem, D-55099 Mainz, Germany Univ Mainz Mainz Germany D-55099 hem & Pathochem, D-55099 Mainz, Germany
Titolo Testata:
BIOCHEMICAL JOURNAL
, volume: 345, anno: 2000,
parte:, 3
pagine: 417 - 421
SICI:
0264-6021(20000201)345:<417:CSPAPT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL TRANSDUCER GP130; PHASE RESPONSE FACTOR; DIFFERENTIAL ACTIVATION; INTERLEUKIN-6; RECEPTOR; EXPRESSION; GENE; PURIFICATION; DIMERIZATION; PROMOTER;
Keywords:
DNA binding; HepG2 hepatoma cells; interleukin-6; A375 melanoma cells; nuclear translocation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Heinrich, PC Rhein Westfal TH Aachen, Inst Biochem, Pauwelsstr 30, D-52074Aachen, Germany Rhein Westfal TH Aachen Pauwelsstr 30 Aachen Germany D-52074
Citazione:
S. Haan et al., "Cytoplasmic STAT proteins associate prior to activation", BIOCHEM J, 345, 2000, pp. 417-421

Abstract

The commonly accepted model of STAT factor activation at the cytoplasmic part of the receptor assumes that signal transducers and activators of transcription (STATs) are recruited from a cytoplasmic pool of monomeric STAT proteins. Based on a previous observation that non-phosphorylated STAT3-Src homology 2 domains dimerize in vitro, we investigated whether the observed dimerization is of physiological relevance within the cellular context. We show that STAT1 and STAT3 are pre-associated in non-stimulated cells. Apparently, these complexes are not able to translocate into the nucleus. We provide evidence that the event of STAT activation is more complex than previously assumed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:25:55