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Titolo:
Mother rats bar-press for pups: effects of lesions of the mpoa and limbic sites on maternal behavior and operant responding for pup-reinforcement (vol 100, pg 15, 1999)
Autore:
Lee, A; Clancy, S; Fleming, AS;
Indirizzi:
Univ Toronto, Dept Psychol, Mississauga, ON L5L 1C6, Canada Univ Toronto Mississauga ON Canada L5L 1C6 ississauga, ON L5L 1C6, Canada
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 108, anno: 2000,
pagine: 213 - 231
SICI:
0166-4328(200003)108:2<213:MRBFPE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; FEMALE RAT; STRIATAL INTERACTIONS; DOPAMINE; AMYGDALA; EXPERIENCE; TIMIDITY; HORMONES;
Keywords:
bar-press; maternal behavior; nucleus accumbens; amygdala; mpoa;
Tipo documento:
Correction, Addition
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Fleming, AS Univ Toronto, Dept Psychol, Mississauga, ON L5L 1C6, Canada Univ Toronto Mississauga ON Canada L5L 1C6 ON L5L 1C6, Canada
Citazione:
A. Lee et al., "Mother rats bar-press for pups: effects of lesions of the mpoa and limbic sites on maternal behavior and operant responding for pup-reinforcement (vol 100, pg 15, 1999)", BEH BRA RES, 108(2), 2000, pp. 213-231

Abstract

This series of studies explored the operant response rates for pup-reinforcement of female Sprague-Dawley rats that were either postpartum or cyclingand sustained lesions of the medial preoptic area (mpoa), the lateral amygdala, the nucleus accumbens, or sham lesions. The last experiment tested the effects on operant responding of preventing direct access to pups in mpoaand sham-lesioned postpartum mothers. All animals were trained prior to mating on an FR-1 bar-press schedule to criterion (50 presses in 30 min) for a food (Froot Loops) reward in an operant chamber. At the end of pregnancy animals that were to be tested postpartum were provided in their home cageswith six newborn foster pups; mother-litter interactions were observed on the last 3 days of pregnancy and throughout the postpartum period. On each of these same days after a period of separation from pups, females were tested in the operant box for delivery of rat pups. With each bar-press response, a rat pup rather than a Fruit Loop was delivered down a gentle shoot into the hopper. Non-postpartum, but maternal, multiparous animals who were showing estrous cycles were tested using the same procedures. The first and second studies showed that animals (both postpartum and as cycling multiparous animals) with mpoa lesions exhibited a significant reduction in bar-press rate for pup reinforcement in the operant box. In postpartum animals, amygdala lesions also produced a bar-press deficit, whereas nucleus accumbenslesions did not. All lesioned groups showed deficits in maternal responding in the home cage and deficits in retrieval in the operant box. These results indicate that systems associated with the mpoa mediate both the stereotypical maternal behaviors and pup-reinforcement. In contrast, the expression of home cage maternal behavior is dependent on the integrity of both the amygdala and nucleus accumbens, whereas operant responding need not be. These results indicate a dissociation of mechanisms mediating expression of the species-typical maternal behavior and pup-reinforcement, (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/09/20 alle ore 04:25:33