Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice
Autore:
Haywood, MEK; Hogarth, MB; Slingsby, JH; Rose, SJ; Allen, PJ; Thompson, EM; Maibaum, MA; Chandler, P; Davies, KA; Simpson, E; Walport, MJ; Morley, BJ;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Rheumatol Sect, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland St Marys Hosp, London, England St Marys Hosp London EnglandSt Marys Hosp, London, England
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 2, volume: 43, anno: 2000,
pagine: 349 - 355
SICI:
0004-3591(200002)43:2<349:IOIOC1>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
Y-CHROMOSOME; ERYTHEMATOSUS; LINKAGE; SUSCEPTIBILITY; TRAITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Morley, BJ Univ London Imperial Coll Sci Technol & Med, Sch Med, RheumatolSect, Hammersmith Campus,Du Cane Rd, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med Hammersmith Campus,Du Cane Rd London England W12 0NN
Citazione:
M.E.K. Haywood et al., "Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice", ARTH RHEUM, 43(2), 2000, pp. 349-355

Abstract

Objective. To identify intervals containing systemic lupus erythematosus (SLE) susceptibility alleles in the BXSB strain of mice. Methods, We analyzed 286 (B10 x [B10 x BXSB]F-1) backcross mice for a range of phenotypic traits associated with the development of SLE in BXSB mice. The mice were genotyped using 93 microsatellite markers, and the linkage of these markers to disease was studied by extreme-phenotype and quantitative trait locus analysis. Results. The disease phenotype in these backcross mice was less severe than that in BXSB mice. However, antinuclear antibody production was increasedcompared with the parental strain, We identified 4 areas of genetic linkage to disease on chromosome 1 (Bxs1-4), 1 on chromosome 3 (Bxs5), and another interval on chromosome 13 which were associated with various aspects of the phenotype. Bxs4 and Bxs5 are located in regions not previously linked todisease in other models of SLE. Conclusion. SLE in the BXSB mouse model has a complex genetic basis and involves at least 5 distinct intervals located on chromosomes 1 and 3. There is evidence that different intervals affect particular aspects of the SLE phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 23:30:03