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Titolo:
Stimulation of the rat dentine-pulp complex by bone morphogenetic protein-7 in vitro
Autore:
Sloan, AJ; Rutherford, RB; Smith, AJ;
Indirizzi:
Univ Birmingham, Sch Dent, Birmingham B4 6NN, W Midlands, England Univ Birmingham Birmingham W Midlands England B4 6NN W Midlands, England Univ Michigan, Sch Dent, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 n, Sch Dent, Ann Arbor, MI 48109 USA
Titolo Testata:
ARCHIVES OF ORAL BIOLOGY
fascicolo: 2, volume: 45, anno: 2000,
pagine: 173 - 177
SICI:
0003-9969(200002)45:2<173:SOTRDC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN OSTEOGENIC PROTEIN-1; GROWTH-FACTOR-BETA; HUMAN DENTAL-PULP; REPARATIVE DENTIN; TOOTH DEVELOPMENT; TGF-BETA; INDUCTION; EXPRESSION; MONKEYS; RECEPTORS;
Keywords:
bone morphogenetic protein-7; reactionary dentine; organ culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Sloan, AJ Univ Birmingham, Sch Dent, St Chads Queensway, Birmingham B4 6NN, W Midlands, England Univ Birmingham St Chads Queensway Birmingham W Midlands England B4 6NN
Citazione:
A.J. Sloan et al., "Stimulation of the rat dentine-pulp complex by bone morphogenetic protein-7 in vitro", ARCH ORAL B, 45(2), 2000, pp. 173-177

Abstract

Human recombinant bone morphogenetic protein-7 (BMP-7), when applied to freshly cut dentine in monkey teeth, stimulated tertiary dentine formation, but it is unclear whether this response involved upregulation of the synthetic and secretory activity of existing odontoblasts or the induction of differentiation of new odontoblast-like cells. Using a recently developed organ-culture system for whole tooth slices, the aim here was to examine the effects of BMP-7 on the stimulation and modulation of existing odontoblasts inthe absence of tissue injury. Agarose beads were soaked in a 500 ng/ml or 100 ng/ml solution of BMP-7 in culture medium and placed on the odontoblastarea of the dentine-pulp complex of rat tooth slices. The slices were embedded in a semisolid agar-based medium and cultured at the liquid-gas interface for 7 days. Results showed that beads soaked in 500 ng/ml BMP-7 stimulated a localized increase in extracellular matrix secretion by odontoblasts at the site of application, with greater stimulatory effects than from the lower concentration. These effects may be important in the reparative processes after tissue injury within the dentine-pulp complex and may be useful in the therapeutic induction of tertiary dentinogenesis. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:49:57