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Titolo:
Alteration in the expression of bone morphogenetic protein-2,3,4,5 mRNA during pathogenesis of cleft palate in BALB/c mice
Autore:
Lu, HB; Jin, Y; Tipoe, GL;
Indirizzi:
Stomatol Coll, Dept Oral Pathol, Xian 710032, Peoples R China Stomatol Coll Xian Peoples R China 710032 , Xian 710032, Peoples R China Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
ARCHIVES OF ORAL BIOLOGY
fascicolo: 2, volume: 45, anno: 2000,
pagine: 133 - 140
SICI:
0003-9969(200002)45:2<133:AITEOB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-MESENCHYMAL INTERACTIONS; EARLY TOOTH DEVELOPMENT; FACIAL PRIMORDIA; BETA SUPERFAMILY; RETINOIC ACID; CHICK LIMB; DIFFERENTIATION; PROTEIN; BMP-4; SKELETOGENESIS;
Keywords:
cleft palate; bone morphogenetic proteins (BMPs); condensation; development; in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, Y Stomatol Coll, Dept Oral Pathol, 1 Kang Fu Rd, Xian 710032, PeoplesR China Stomatol Coll 1 Kang Fu Rd Xian Peoples R China 710032 les R China
Citazione:
H.B. Lu et al., "Alteration in the expression of bone morphogenetic protein-2,3,4,5 mRNA during pathogenesis of cleft palate in BALB/c mice", ARCH ORAL B, 45(2), 2000, pp. 133-140

Abstract

To identify the function of these bone morphogenetic proteins (BMP) duringpathogenesis of cleft palate, an experimental model was established in BALB/c mice. Cleft palate was induced by exposure to retinoic acid on embryonic day (E)12. The expression of BMP-2,3,4,5 mRNA in normal and abnormal embryonic palatal shelves was then examined from E13 to E16 by in situ hybridization. The results showed that BMP-4 mRNA was expressed strongly and uniformly in normal epithelial cells and dispersed mesenchymal cells on E13. BMP-2,5 mRNA expression appeared only in dispersed mesenchymal cells. With the development of shelves, the staining density of BMP-2,4,5 decreased gradually in mesenchymal cells outside of the condensation and increased inside the condensation. After shelves had fused on E16, no positive signals for BMP-2,4,5 were detected in dispersed mesenchymal cells, but their expression persisted in the condensation. Exposure to retinoic acid delayed the formation of the condensation and decreased BMP-2,4,5 mRNA dramatically in mesenchyme from E13 to E15. BMP-3 mRNA expression were almost negative in either control or retinoic acid-treated groups during all stages. It was concluded that spatial and temporal expression of BMP-2,4,5 was required during normal palatogenesis, and that a deficiency of their mRNA expression may contribute to the pathogenesis of cleft palate. (C) 2000 Elsevier Science Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:27:24