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Titolo:
Racial differences in response to acute dosing with hydrochlorothiazide
Autore:
Ripley, E; King, K; Sica, DA;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Div Nephrol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Div Clin Pharmacol & Hypertens, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 2, volume: 13, anno: 2000,
pagine: 157 - 164
SICI:
0895-7061(200002)13:2<157:RDIRTA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; PLASMA-RENIN ACTIVITY; ESSENTIAL HYPERTENSION; VOLUME; ALDOSTERONE; BLACK; PHARMACOKINETICS; ELECTROLYTES; EXCRETION; PRESSURE;
Keywords:
hydrochlorothiazide; dose-response; pharmacokinetics; pharmacodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ripley, E Virginia Commonwealth Univ, Med Coll Virginia, Div Nephrol, Box 980160, Richmond, VA 23298 USA Virginia Commonwealth Univ Box 980160 Richmond VA USA 23298 USA
Citazione:
E. Ripley et al., "Racial differences in response to acute dosing with hydrochlorothiazide", AM J HYPERT, 13(2), 2000, pp. 157-164

Abstract

Blacks demonstrate a higher response rate to diuretic therapy for hypertension than do whites. This study examined the pharmacokinetic (PK), pharmacodynamic, and neurohumoral effects of hydrochlorothiazide (HCTZ) administration in a matched group of 9 black and 9 white hypertensive patients (mean +/- SD for black and white). After a 4-week washout period and 7-day controldiet, subjects received a single dose of HCTZ (25 mg at 8 AM) With Serial blood and urine collections for 36 hours. After HCTZ sodium excretion increased comparably in both groups (blacks: 122 +/- 42 pre to 265 +/- 49 mEq/24hours post; whites: 117 +/- 29 pre to 255 +/- 39 mEq/24 hrs post). Potassium excretion tended to be higher at baseline and was significantly higher following HCTZ in whites (blacks: 45 +/- 20 pre to 66 +/- 13 mEq at 24 hourspost; blacks: 57 +/- 9 pre to 86 +/- 14 mEq at 24 hours post) with most ofthe post-dosing difference being observed in the hours 0 to 12 after HCTZ. There were no between group PK differences for urinary HCTZ. Aldosterone excretion followed a normal circadian pattern in the whites but did not showthis pattern in the blacks. Aldosterone excretion (0 to 12 hours) was generally lower post-dosing in blacks. In conclusion, whereas the PK and single-dose natriuretic response for HCTZ were not racially distinct, potassium excretion was notably less in blacks. Aldosterone excretion was also lower in blacks and without its normal circadian pattern which may, in part, explain their altered potassium excretion pattern. (C) 2000 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:29:58