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Titolo:
Myocardial infarction and left ventricular remodeling: Results of the CEDIM trial
Autore:
Colonna, P; Iliceto, S;
Indirizzi:
Univ Cagliari, Inst Cardiol, Cagliari, Italy Univ Cagliari Cagliari Italy iv Cagliari, Inst Cardiol, Cagliari, Italy
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 2, volume: 139, anno: 2000,
parte:, 3 supplemento:, S
pagine: S124 - S130
SICI:
0002-8703(200002)139:2<S124:MIALVR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY; L-CARNITINE; METABOLISM; VIABILITY; CAPTOPRIL; SURVIVAL; SIZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Iliceto, S Univ Cagliari, Osped S Giovanni di Rio, Div Cardiol, Inst Cardiol, Via Osped 46, I-09124 Cagliari, Italy Univ Cagliari Via Osped 46 Cagliari Italy I-09124 liari, Italy
Citazione:
P. Colonna e S. Iliceto, "Myocardial infarction and left ventricular remodeling: Results of the CEDIM trial", AM HEART J, 139(2), 2000, pp. S124-S130

Abstract

Left ventricular dilatation after acute myocardial infarction (MI) is a powerful predictor of progressive functional deterioration, culminating in heart failure and death. The most important determinants of post-Mi left ventricular remodeling are the size of the infarct, the degree of residual stenosis in the infarct-related artery, and the viability of the infarct zone. In addition to reperfusion therapy and angiotensin-converting enzyme inhibition, metabolic intervention with L-carnitine may represent a therapeutic approach for preventing left ventricular dilatation and preserving cardiac function. Ongoing studies with early metabolic intervention with carnitine in the acute phase of infarction may prove successful in protecting the microcirculation against ischemic damage and enhancing its ability to respond to blood flow resumption. The results of the multicenter, randomized, double-blind Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) trial suggest that the early and long-term administration of L-carnitine attenuates progressive left ventricular dilatation after acute anterior MI. Results show significant, consistent reductions in end-diastolic volume and end-systolic volume in patients who received L-carnitine compared with placebo. The ongoing CEDIM-2 trial (projected 4000 patients with acute MI) will assess the efficacy of I-carnitine in reducing the combined incidence of death and heart failure at 6 months. in addition to standard reperfusion therapy and angiotensin-converting enzyme inhibition, metabolic intervention with L-carnitine may be ct therapeutic approach for pro venting left ventricular dilatation and preserving cardiac function by limiting infarct size, decreasing residual stenosis in the infarct-related artery, and increasing viability of the infarct zone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:43:27