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Titolo:
Involvement of nicotinic receptors in alcohol self-administration
Autore:
Le, AD; Corrigall, WA; Harding, JWS; Juzytsch, W; Li, TK;
Indirizzi:
Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON M5S 2S1, Canada Univ Toronto Toronto ON Canada M5S 2S1 Hlth, Toronto, ON M5S 2S1, Canada Indiana Univ, Sch Med, Dept Med, Indianapolis, IN USA Indiana Univ Indianapolis IN USA Sch Med, Dept Med, Indianapolis, IN USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 2, volume: 24, anno: 2000,
pagine: 155 - 163
SICI:
0145-6008(200002)24:2<155:IONRIA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; INDUCED DOPAMINE RELEASE; RAT NUCLEUS-ACCUMBENS; SHORT-SLEEP MICE; LOCOMOTOR-ACTIVITY; ACETYLCHOLINE-RECEPTOR; SYNAPTIC DOPAMINE; LONG-SLEEP; ETHANOL; MECAMYLAMINE;
Keywords:
nicotine; mecamylamine; dihydro-beta-erythroidine; alcohol self-administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Le, AD Univ Toronto, Ctr Addict & Mental Hlth, 31 Russell St, Toronto, ON M5S 2S1, Canada Univ Toronto 31 Russell St Toronto ON Canada M5S 2S1 5S 2S1, Canada
Citazione:
A.D. Le et al., "Involvement of nicotinic receptors in alcohol self-administration", ALC CLIN EX, 24(2), 2000, pp. 155-163

Abstract

Background: Alcohol and nicotine, in the form of tobacco. are commonly co-abused. Nicotinic receptors also have been implicated in alcohol action. Wedesigned the present study to examine the possible involvement of nicotinic receptors in alcohol self-administration. Methods and Results: Pretreatment with lower doses (0.1-0.4 mg/kg) of nicotine, administered acutely or chronically, did not affect alcohol consumption, whereas a higher dose (0.8 mg/kg) initially suppressed alcohol consumption but stimulated alcohol consumption on repeated treatment. We observed the same pattern of nicotine effects on alcohol self-administration using anoperant procedure. A dose of 0.8 mg/kg of nicotine initially suppressed operant responding for alcohol. Such suppression of alcohol self-administration was more pronounced during the first 20 min of the 60 min operant session. Responding for alcohol in the nicotine treated group, however, was significantly increased above the saline treated group by the 5th day of treatment. Mecamylamine, a noncompetitive nicotinic receptor antagonist, reduced alcohol consumption, whereas dihydro-beta-erythroidine (DH beta E), a competitive nicotinic receptor antagonist, did nor modify alcohol consumption. Conclusions: The stimulation of alcohol intake induced by nicotine treatment and the suppression of alcohol intake induced by mecamylamine provide evidence for the involvement of nicotinic receptors in alcohol consumption and/or self-administration. The failure of DH beta E to reduce alcohol consumption, however, suggests that ethanol-nicotine interaction is mediated by other nicotinic receptor subtypes rather than alpha 4 beta 2 receptor subtype, or that mecamylamine acts through a nonnicotinic mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:14:23