Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dopamine D-2 receptor imaging in Gilles de la Tourette syndrome
Autore:
Muller-Vahl, KR; Berding, G; Kolbe, H; Meyer, GJ; Hundeshagen, H; Dengler, R; Knapp, WH; Emrich, HM;
Indirizzi:
Hannover Med Sch, Dept Clin Psychiat & Psychotherapy, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 apy, D-30625 Hannover, Germany Hannover Med Sch, Dept Neurol, D-30625 Hannover, Germany Hannover Med SchHannover Germany D-30625 rol, D-30625 Hannover, Germany Hannover Med Sch, Dept Nucl Med, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 Med, D-30625 Hannover, Germany
Titolo Testata:
ACTA NEUROLOGICA SCANDINAVICA
fascicolo: 3, volume: 101, anno: 2000,
pagine: 165 - 171
SICI:
0001-6314(200003)101:3<165:DDRIIG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 IBZM; HUMAN-BRAIN; SPECT; BINDING; PET; RACLOPRIDE; DISEASE; INVITRO; UPDATE; SITES;
Keywords:
Gilles de la Tourette syndrome; tics; IBZM-SPECT; pathology; dopamine receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Muller-Vahl, KR Hannover Med Sch, Dept Clin Psychiat & Psychotherapy, CarlNeuberg Str 1, D-30625 Hannover, Germany Hannover Med Sch Carl Neuberg Str1 Hannover Germany D-30625
Citazione:
K.R. Muller-Vahl et al., "Dopamine D-2 receptor imaging in Gilles de la Tourette syndrome", ACT NEUR SC, 101(3), 2000, pp. 165-171

Abstract

Objectives - To examine postsynaptic dopamine D-2 receptors in Tourette syndrome (TS). Material and methods - Seventeen patients and a control group were investigated using single photon emission computed tomography (SPECT) and iodobenzamide (I-123-IBZM). Results - In neuroleptic treated patients (n = 7) I-123-IBZM-binding was significantly reduced compared to both normalcontrols (P < 0.0001) and unmedicated patients (P < 0.001). In unmedicatedpatients (n = 10) mean binding ratio did not differ from that of control group. Patients in advanced stages of the disease, however, revealed significantly reduced relative striatal binding compared to patients in the early stages (P < 0.005) and normal controls (P < 0.0001). Conclusion - The results lend further support to the hypothesis that the dopamine receptor is involved in TS pathology. During the natural course of the disease ties often improve in early adulthood. It is suggested that this spontaneous recovery from ties may be associated with reduced receptor binding capacity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:14:19