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Titolo:
Circulating tissue-type plasminogen activator and plasminogen activator inhibitor type 1 in proliferative diabetic retinopathy: a pilot study
Autore:
Simpson, AJ; Booth, NA; Moore, NR; Lewis, SJ; Gray, RS;
Indirizzi:
St Johns Hosp, Dept Med, Livingston EH54 6PP, Scotland St Johns Hosp Livingston Scotland EH54 6PP Livingston EH54 6PP, Scotland Univ Aberdeen, Dept Mol & Cell Biol, Aberdeen AB25 2ZD, Scotland Univ Aberdeen Aberdeen Scotland AB25 2ZD ol, Aberdeen AB25 2ZD, Scotland Royal Coll Phys Edinburgh, Edinburgh EH2 1JQ, Midlothian, Scotland Royal Coll Phys Edinburgh Edinburgh Midlothian Scotland EH2 1JQ Scotland
Titolo Testata:
ACTA DIABETOLOGICA
fascicolo: 3, volume: 36, anno: 1999,
pagine: 155 - 158
SICI:
0940-5429(199909)36:3<155:CTPAAP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRINOLYTIC SYSTEM; HEMOSTATIC VARIABLES; CHRONIC SMOKING; MELLITUS; PLASMA; PLATELETS; MICROANGIOPATHY; COMPLICATIONS; NEPHROPATHY; ANTIGEN;
Keywords:
diabetes; retinopathy; fibrinolysis; plasma; platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Simpson, AJ Univ Edinburgh, Sch Med, Rayne Lab, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Teviot Pl Edinburgh Midlothian Scotland EH8 9AG
Citazione:
A.J. Simpson et al., "Circulating tissue-type plasminogen activator and plasminogen activator inhibitor type 1 in proliferative diabetic retinopathy: a pilot study", ACT DIABETO, 36(3), 1999, pp. 155-158

Abstract

Several haemostatic abnormalities are associated with proliferative diabetic retinopathy. While abnormalities in plasma fibrinolytic activity have been described in diabetic retinopathy, platelets (a rich source of plasminogen activator inhibitor type 1, PAI-1) have received little attention. As a result, little is known about the fibrinolytic potential of circulating whole blood in diabetic retinopathy. The concentrations trations of tissue-type plasminogen activator (t-PA) and of its fast-acting inhibitor, PAI-1 weremeasured in plasma from eight patients with type 1 diabetes complicated byproliferative retinopathy, and from eight patients with type 1 diabetes and background or no retinopathy, matched for age, sex and duration of diabetes. The concentration of PAI-1 in platelets was also measured. The ratio oft-PA to PAI-1 in plasma was significantly higher in patients with proliferative retinopathy than in those without (0.66 vs. 0.37, p < 0.02). The average quantity of PAI-1 per platelet was significantly lower in the group with proliferative retinopathy (0.33 vs. 0.50 ng/10(6) platelets, p < 0.02). These data suggest that among patients with type 1 diabetes, total circulating fibrinolytic potential is higher in those with proliferative retinopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:33:09