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Titolo:
Measurement of serum hyaluronate as a predictor of human liver failure after major hepatectomy
Autore:
Yachida, S; Wakabayashi, H; Kokudo, Y; Goda, F; Okada, S; Maeba, T; Maeta, H;
Indirizzi:
Kagawa Med Univ, Fac Med, Dept Surg 1, Miki, Kagawa 7610793, Japan Kagawa Med Univ Miki Kagawa Japan 7610793 1, Miki, Kagawa 7610793, Japan
Titolo Testata:
WORLD JOURNAL OF SURGERY
fascicolo: 3, volume: 24, anno: 2000,
pagine: 359 - 364
SICI:
0364-2313(200003)24:3<359:MOSHAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL-VEIN EMBOLIZATION; SINUSOIDAL ENDOTHELIAL-CELLS; MASSIVE HEPATIC-NECROSIS; HEPATOCELLULAR-CARCINOMA; BACTERIAL TRANSLOCATION; CIRRHOTIC-PATIENTS; KUPFFER CELLS; RAT-LIVER; RESECTION; ENDOTOXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Yachida, S Kagawa Med Univ, Fac Med, Dept Surg 1, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan Kagawa Med Univ 1750-1 Ikenobe Miki Kagawa Japan 7610793 Japan
Citazione:
S. Yachida et al., "Measurement of serum hyaluronate as a predictor of human liver failure after major hepatectomy", WORLD J SUR, 24(3), 2000, pp. 359-364

Abstract

Serum hyaluronate can be used as an index of hepatic sinusoidal endothelial cell function. This study was designed to evaluate its application as a predictor of liver failure after major hepatectomy. Thirty-six patients who underwent right liver lobectomy after percutaneous transhepatic right branch portal vein embolization were divided into two groups based on their postoperative clinical course (groups 1 and 2, with and without postoperative liver failure, n = 6 and n = 30, respectively). We serially measured serum hyaluronate levels using a sandwich binding protein assay system before and after hepatectomy and determined relations with progression of the underlying chronic liver disorder, portal venous pressure, and liver growth of the left lobe after portal embolization. Serum hyaluronate levels were significantly elevated, in line with the degree of severity of the underlying chronic liver disorder, and correlated well with the portal venous pressure and the hypertrophic ratio of the left lobe subsequent to portal embolization. Serum hyaluronate levels in group 1 were significantly higher than those ingroup 2 before surgery and increased steeply during the early period afterhepatectomy. These results suggest that the serum hyaluronate reflects thehepatic functional reserve, and serial measurement of this parameter afterhepatectomy can serve as a simple indicator for early detection of posthepatectomy liver failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:24:42