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Titolo:
Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine
Autore:
Nixon, DF; Donahoe, SM; Kakimoto, WM; Samuel, RV; Metzner, KJ; Gettie, A; Hanke, T; Marx, PA; Connor, RI;
Indirizzi:
Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA Rockefeller Univ New York NY USA 10016 DS Res Ctr, New York, NY 10016 USA John Radcliffe Hosp, Inst Mol Med, MRC, Human Immunol Unit, Oxford OX3 9DS, England John Radcliffe Hosp Oxford England OX3 9DS Unit, Oxford OX3 9DS, England Tulane Univ, Med Ctr, Dept Trop Med, Covington, LA 70433 USA Tulane Univ Covington LA USA 70433 Dept Trop Med, Covington, LA 70433 USA Tulane Univ, Med Ctr, Reg Primate Res Ctr, Covington, LA 70433 USA Tulane Univ Covington LA USA 70433 imate Res Ctr, Covington, LA 70433 USA
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 266, anno: 2000,
pagine: 203 - 210
SICI:
0042-6822(20000105)266:1<203:SIVCTL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTRALIZING ANTIBODIES; SIV REPLICATION; CTL EPITOPE; MONKEYS; RESISTANCE; RESPONSES; INFECTION; CELLS; HIV; PROSTITUTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Nixon, DF Rockefeller Univ, Aaron Diamond AIDS Res Ctr, 455 1st Ave, New York, NY 10016 USA Rockefeller Univ 455 1st Ave New York NY USA 10016 NY 10016 USA
Citazione:
D.F. Nixon et al., "Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine", VIROLOGY, 266(1), 2000, pp. 203-210

Abstract

In this study, we examined the role of simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes (CTLs) in macaques immunized with an attenuated strain of simian immunodeficiency virus (SIVmac239 Delta nef) in protection against pathogenic challenge with SIVmac251. Our results indicate that attenuated SIVmac239 Delta nef can elicit specific CTL precursor cells (CTLp), but no correlation was observed between breadth or strength of CTLpresponse to structural proteins SIV-Env, -Gamg or -Pol (as measured by limiting dilution assay) and protection against infection. In one animal, we longitudinally followed the SIV-Gag-specific response to an MHC class I Mamu-A*01-restricted epitope p11C, C-M using a tetrameric MHC/peptide complex reagent. A low frequency of SIV p11C, C-M peptide-specific tetramer-reactivecells was present at the lime of challenge but could be expanded in vitro. Surprisingly, the tow level of Mamu-A*01/p11C, C-M-specific CTLs induced through attenuated SIVmac239 Delta nef vaccination increased in the absence of detectable SIVmac251 or SIVmac239 Delta nef proviral DNA. Overall, our results suggest that protection against infection in this model can be achieved through more than one mechanism, with SIV-specific CTLs being importantin controlling SIVmac239 Delta nef viral replication postchallenge. (C) 2000 Academic Press.

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Documento generato il 19/09/20 alle ore 15:26:01