Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Maternal morphine alters parvalbumin immunoreactivity patterns in neonatalmouse brain
Autore:
Maharajan, P; Prencipe, R; Di Francesco, P; Paino, G; Ravagnan, G; Maharajan, V;
Indirizzi:
CNR, Inst Cybernet, I-80072 Arco, Naples, Italy CNR Arco Naples Italy I-80072 Inst Cybernet, I-80072 Arco, Naples, Italy Univ Roma Tor Vergata, Dept Expt Med, Rome, Italy Univ Roma Tor Vergata Rome Italy or Vergata, Dept Expt Med, Rome, Italy Univ Naples Federico II, Dept Struct Funct & Biol Technol, Naples, Italy Univ Naples Federico II Naples Italy unct & Biol Technol, Naples, Italy CNR, Inst Expt Med, Rome, Italy CNR Rome ItalyCNR, Inst Expt Med, Rome, Italy
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 35, anno: 2000,
pagine: 265 - 271
SICI:
0887-4476(20000315)35:4<265:MMAPIP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MU-OPIOID RECEPTOR; ANTERIOR CINGULATE CORTEX; RAT HIPPOCAMPUS; INHIBITORY INTERNEURONS; SELECTIVE VULNERABILITY; CEREBRAL-CORTEX; CALBINDIN D28K; NEURONS; FOREBRAIN; NEOCORTEX;
Keywords:
neonatal brain; morphine; parvalbumin; cingulate cortex; parietal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Maharajan, V CNR, Inst Cybernet, I-80072 Arco, Naples, Italy CNR Arco Naples Italy I-80072 t, I-80072 Arco, Naples, Italy
Citazione:
P. Maharajan et al., "Maternal morphine alters parvalbumin immunoreactivity patterns in neonatalmouse brain", SYNAPSE, 35(4), 2000, pp. 265-271

Abstract

The influence of chronic maternal morphine on the parvalbumin immunoreactive patterns in developing mouse brain was studied. Female Swiss mice were administered daily saline or morphine (30 or 60 mg/kg) for a period of 7 days before mating, gestation, and 21 days postpartum. Their pups were sacrificed on postnatal day 18 and the brains were examined histologically and immunohistochemically for parvalbumin-positive neurons. Histological observations revealed no significant changes in the cell number of the morphine-exposed neonatal forebrain, whereas the number of parvalbumin-positive neurons increased in layers II-IV of the parietal cortex I. Moreover, the number ofparvalbumin-positive dendrites increased remarkably in the cingulate and parietal I cortices of the morphine-exposed neonates, indicating the region-specific increase in the PV immunoreactive profiles. These results are consistent with the key roles played by the above brain regions in the altered behavioral patterns of the maternally addicted neonates, such as impaired somatosensory and cognitive performances. The mechanism of morphine action on parvalbumin expression in neonatal mouse brain is not evident, but alterations in the expression patterns of parvalbumin in specific regions of the developing brain might be one of the cellular mechanisms by which addictivedrugs modify the functional aspects of the developing CNS. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:27:58