Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Platelet [H-3]paroxetine binding in patients with OCD-related disorders
Autore:
Marazziti, D; DellOsso, L; Presta, S; Pfanner, C; Rossi, A; Masala, I; Baroni, S; Giannaccini, G; Lucacchini, A; Cassano, GB;
Indirizzi:
Univ Pisa, Dipartimento Psichiatria Neurobiol Farmacol & Bio, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 urobiol Farmacol & Bio, I-56100 Pisa, Italy
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 3, volume: 89, anno: 1999,
pagine: 223 - 228
SICI:
0165-1781(199912)89:3<223:P[BIPW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; H-3 PAROXETINE BINDING; ANXIETY-RELATED TRAITS; IMIPRAMINE BINDING; SEROTONIN TRANSPORTER; POLYMORPHISM; EFFICACY;
Keywords:
obsessive-compulsive disorder (OCD); OCD spectrum disorders; serotonin; serotonin transporter; platelets; [H-3]paroxetine binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Marazziti, D Univ Pisa, Dipartimento Psichiatria Neurobiol Farmacol & Bio,Via Roma 67,I-56100 Pisa, Italy Univ Pisa Via Roma 67 Pisa Italy I-56100 I-56100 Pisa, Italy
Citazione:
D. Marazziti et al., "Platelet [H-3]paroxetine binding in patients with OCD-related disorders", PSYCHIAT R, 89(3), 1999, pp. 223-228

Abstract

The recently introduced notion of clinical conditions being related one toanother, the spectrum concept, permits the testing of the involvement of serotonergic systems in a broad range of disorders tentatively linked to obsessive-compulsive disorder (OCD) for which no pathophysiological hypothesesyet exist. We therefore compared the binding of [H-3]paroxetine ([H-3]Par), a ligand that specifically labels the serotonin (5-HT) transporter, in platelets of drug-free outpatients suffering from various OCD-related disorders with binding in platelets of OCD patients and healthy subjects. Diagnoses were made according to DSM-IV criteria. The most frequent diagnosis was that of body dysmorphic disorder, followed by impulse control disorder, kleptomania, Tourette's syndrome and trichotillomania. Platelet membranes and [H-3]Par binding were studied according to standardized protocols. The results, showing a similarly decreased density of [H-3]Par binding sites in bothpatient groups as compared with healthy subjects, suggest the presence of a shared abnormality at the level of the presynaptic 5-HT transporter, probably linked to a common dimension yet to be identified. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:30:25