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Titolo:
Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat
Autore:
Paulson, PE; Morrow, TJ; Casey, KL;
Indirizzi:
VA Med Ctr, Neurol Res Labs, Ann Arbor, MI 48105 USA VA Med Ctr Ann ArborMI USA 48105 eurol Res Labs, Ann Arbor, MI 48105 USA Univ Michigan, Dept Neurol, Ann Arbor, MI 48105 USA Univ Michigan Ann Arbor MI USA 48105 Dept Neurol, Ann Arbor, MI 48105 USA Univ Michigan, Dept Physiol, Ann Arbor, MI 48105 USA Univ Michigan Ann Arbor MI USA 48105 ept Physiol, Ann Arbor, MI 48105 USA
Titolo Testata:
PAIN
fascicolo: 2-3, volume: 84, anno: 2000,
pagine: 233 - 245
SICI:
0304-3959(200002)84:2-3<233:BBARCB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ROSTRAL VENTROMEDIAL MEDULLA; PRIMARY SOMATOSENSORY CORTEX; NEUROPATHIC PAIN; SPINAL-CORD; PERIAQUEDUCTAL GRAY; NERVE INJURY; FORMALIN-TEST; OFF-CELLS;
Keywords:
chronic pain; chronic constriction injury; sciatic nerve; neuroimaging; regional cerebral blood flow; rat;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Paulson, PE VA Med Ctr, Neurol Res Labs, 11R 2215 Fuller Rd, Ann Arbor, MI48105 USA VA Med Ctr 11R 2215 Fuller Rd Ann Arbor MI USA 48105 48105 USA
Citazione:
P.E. Paulson et al., "Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat", PAIN, 84(2-3), 2000, pp. 233-245

Abstract

A unilateral chronic constriction injury (CCI) of the sciatic nerve produced bilateral effects in both pain related behaviors and in the pattern of forebrain activation. All CCI animals exhibited spontaneous pain-related behaviors as well as bilateral hyperalgesia and allodynia after CCI. Further, we identified changes in baseline (unstimulated) forebrain activation patterns 2 weeks following CCI by measuring regional cerebral blood Row (rCBF). Compared to controls, CCI consistently produced detectable, well-localized and typically bilateral increases in rCBF within multiple forebrain structures in unstimulated animals. For example, the hindlimb region of somatosensory cortex was significantly activated (22%) as well as multiple thalamc nuclei, including the ventral medial (8%), ventral posterior lateral (10%) and the posterior (9%) nuclear groups. In addition, several forebrain regionsconsidered to be part of the limbic system showed pain-induced changes in rCBF, including the anterior dorsal nucleus of the thalamus (23%), cingulate cortex (18%), retrosplenial cortex (30%), habenular complex (53%), interpeduncular nucleus (45%) and the paraventricular nucleus of the hypothalamus(30%). Our results suggest that bilateral somatosensory and limbic forebrain structures participate in the neural mechanisms of prolonged persistent pain produced by a unilateral injury. Published for the International Association for the Study of Pain by Elsevier Science B.V.

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Documento generato il 30/03/20 alle ore 10:03:34