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Titolo:
Allelic imbalance at NBS1 is frequent in both proximal and distal colorectal carcinoma
Autore:
Uhrhammer, N; Bay, JO; Gosse-Brun, S; Kwiatkowski, F; Rio, P; Daver, A; Bignon, YJ;
Indirizzi:
Ctr Jean Perrin, Mol Oncol Lab, INSERM CRI 9502, F-63011 Clermont Ferrand,France Ctr Jean Perrin Clermont Ferrand France F-63011 Clermont Ferrand,France Ctr Jean Perrin, EA 2145, F-63011 Clermont Ferrand, France Ctr Jean Perrin Clermont Ferrand France F-63011 Clermont Ferrand, France Ctr Paul Papin, Serv Radiotherapie, F-49033 Angers, France Ctr Paul PapinAngers France F-49033 diotherapie, F-49033 Angers, France Ctr Jean Perrin, F-63011 Clermont Ferrand, France Ctr Jean Perrin Clermont Ferrand France F-63011 Clermont Ferrand, France INSERM U484, Clermont Ferrand, France INSERM U484 Clermont Ferrand France SERM U484, Clermont Ferrand, France
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 2, volume: 7, anno: 2000,
pagine: 427 - 431
SICI:
1021-335X(200003/04)7:2<427:AIANIF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIJMEGEN-BREAKAGE-SYNDROME; DOUBLE-STRAND BREAKS; HEPATOCELLULAR-CARCINOMA; DNA-DAMAGE; CANCER; DELINEATION; INSTABILITY; ALLELOTYPE; RESPONSES; PROTEIN;
Keywords:
colorectal cancer; chromosomal instability; Nijmegen breakage syndrome; ataxia-telangiectasia; allelic imbalance; loss of heterozygosity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Uhrhammer, N Ctr Jean Perrin, Mol Oncol Lab, INSERM CRI 9502, 58 Rue Montalembert, F-63011 Clermont Ferrand, France Ctr Jean Perrin 58 Rue Montalembert Clermont Ferrand France F-63011
Citazione:
N. Uhrhammer et al., "Allelic imbalance at NBS1 is frequent in both proximal and distal colorectal carcinoma", ONCOL REP, 7(2), 2000, pp. 427-431

Abstract

Nijmegen breakage syndrome (NBS) is a hereditary disorder involving chromosomal instability, cancer risk and radiosensitivity. NBS carriers have an increased risk of cancer, though the significance of mutations in the NBS1 gene in sporadic cancer has not yet been investigated. Because the loss of NBS1 is associated with increased chromosomal rearrangements, and tumors of the colon are particularly prone to chromosomal anomalies, we have begun tostudy the NBS1 locus in colorectal cancer (CRC). DNA was isolated from 99 microdissected colorectal tumors, and micro-satellite markers flanking the NBS1 locus at 8q21.3 as well as elsewhere on 8q were analyzed. Normal lymphocyte DNA from each patient served to normalize the amplification of each allele, and a reduction of at least 35% in the intensity of one allele was taken as evidence of allelic imbalance (AI). In proximal and distal CRCs we found 25.9 and 36.2% with AI at 8q21.3, respectively. AI in proximal CRC tended not to extend to marker D8S555 at 8q24.1, whereas in distal CRC the region of AI frequently included all the informative markers. AI of 8q21.3 was not associated with any clinical variable. These results suggest that 8q21.3 contains a tumor suppressor gene involved in proximal CRC, possibly NBS1. The large regions of AI make it difficult to determine the importance ofAI at the NBSI locus in distal CRC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:11:01