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Titolo:
A novel monoclonal antibody, H9, directed against the core protein of MUC1mucin
Autore:
Hamada, H; Kohno, N; Yokoyama, A; Kondo, K; Yang, SZ; Hiwada, K; Watanabe, K; Miyake, M;
Indirizzi:
Ehime Univ, Sch Med, Dept Internal Med 2, Matsuyama, Ehime 7910295, Japan Ehime Univ Matsuyama Ehime Japan 7910295 Matsuyama, Ehime 7910295, Japan Eizai Co Ltd, Bunkyo Ku, Tokyo, Japan Eizai Co Ltd Tokyo JapanEizai Co Ltd, Bunkyo Ku, Tokyo, Japan Tazuke Kofukai Med Res Inst, Dept Thorac Surg, Osaka, Japan Tazuke KofukaiMed Res Inst Osaka Japan Dept Thorac Surg, Osaka, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 2, volume: 7, anno: 2000,
pagine: 225 - 232
SICI:
1021-335X(200003/04)7:2<225:ANMAHD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER-ASSOCIATED ANTIGEN; TUMOR-ASSOCIATED ANTIGENS; MEDIATED CELL-ADHESION; INTERSTITIAL PNEUMONITIS; CARBOHYDRATE ANTIGEN; LUNG ADENOCARCINOMA; BREAST CARCINOMA; EPISIALIN MUC1; EXPRESSION; KL-6;
Keywords:
cancer-associated mucin; MUC1 mucin; H9 antibody; KL-6 antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kohno, N Ehime Univ, Sch Med, Dept Internal Med 2, Matsuyama, Ehime 7910295, Japan Ehime Univ Matsuyama Ehime Japan 7910295 a, Ehime 7910295, Japan
Citazione:
H. Hamada et al., "A novel monoclonal antibody, H9, directed against the core protein of MUC1mucin", ONCOL REP, 7(2), 2000, pp. 225-232

Abstract

MUC1 mucin is a target protein for many monoclonal antibodies. Human MUC1 detected by a murine anti-KL-6 monoclonal antibody that recognizes a sialylated carbohydrate chain has been designated KL-6/MUC1. Given the heterogeneous antigenicity of KL-6/MUC1, we established a new murine monoclonal antibody, H9, that reacts with epitope DTRP (Asp-Thr-Arg-Pro) peptides within the immunodominant region of the tandem repeat of MUC1 mucin. The reactivity of the H9 antibody differs from that of other previously reported antibodies that recognize the tandem repeat region of MUC1. Immunohistochemical experiments indicate that the reactivity of the H9 antibody is similar to that of other antibodies directed against MUC1 core proteins. A new cancer-associated protein detected by a sandwich assay using the H9 antibody as a catcher and the KL-6 antibody as a tracer is designated HK9. Serum HK9 levels showed a high expression level in lung cancer: 51% (19/37 cases) for adenocarcinoma, 39% (11/28 cases) for squamous cell carcinoma, and 67% (10/15 cases) for small cell carcinoma. The HK9 expression in lung cancer increased with cancer progression. These findings suggest monoclonal antibody H9 to be anovel antibody that reacts with an epitope within the tandem repeat regionof MUC1, and that the cancer-associated antigen HK9 may have useful tumor-associated properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:38:23