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Titolo:
Structured triacylglycerol emulsion, containing both medium- and long-chain fatty acids, in long-term home parenteral nutrition: A double-blind randomized cross-over study
Autore:
Rubin, M; Moser, A; Vaserberg, N; Greig, F; Levy, Y; Spivak, H; Ziv, Y; Lelcuk, S;
Indirizzi:
Beilinson Med Ctr, Dept Surg B, IL-49100 Petah Tiqwa, Israel Beilinson MedCtr Petah Tiqwa Israel IL-49100 -49100 Petah Tiqwa, Israel Felsenstein Med Res Ctr, Petah Tikva, Israel Felsenstein Med Res Ctr Petah Tikva Israel Res Ctr, Petah Tikva, Israel Tel Aviv Univ, Sackler Sch Med, Assaf Harofeh Med Ctr, Dept Surg B, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 Surg B, IL-69978 Tel Aviv, Israel HaEnek Med Ctr, Dept Med A, Tel Aviv, Israel HaEnek Med Ctr Tel Aviv Israel ek Med Ctr, Dept Med A, Tel Aviv, Israel
Titolo Testata:
NUTRITION
fascicolo: 2, volume: 16, anno: 2000,
pagine: 95 - 100
SICI:
0899-9007(200002)16:2<95:STECBM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIGLYCERIDE EMULSIONS; POSTOPERATIVE-PATIENTS; LIPOPROTEIN-LIPASE; HEPATIC LIPASE; LIVER-DISEASE; METABOLISM; PROTEIN; RATS; CHOLESTEROL; CHOLESTASIS;
Keywords:
home total parenteral nutrition; structured triacylglycerol; medium-chain fatty acids; long-chain fatty acids; lipid emulsion; structolipid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Rubin, M Beilinson Med Ctr, Dept Surg B, IL-49100 Petah Tiqwa, Israel Beilinson Med Ctr Petah Tiqwa Israel IL-49100 tah Tiqwa, Israel
Citazione:
M. Rubin et al., "Structured triacylglycerol emulsion, containing both medium- and long-chain fatty acids, in long-term home parenteral nutrition: A double-blind randomized cross-over study", NUTRITION, 16(2), 2000, pp. 95-100

Abstract

Structured lipid emulsion, an innovative approach in which both medium-chain and long-chain fatty acids are esterified to the same glycerol backbone,has been recently shown to be a safe and efficient way of providing energyto patients requiring parenteral nutrition. As yet, no assessment has beenmade of its safety and effect on Liver functions during long-term treatment. Twenty-two home parenteral nutrition patients with Crohn's disease or short bowel syndrome were enrolled in a double-blind randomized, cross-over study. Twenty patients who completed the study were treated for 4 wk with a structured lipid emulsion and for 4 wk with long-chain triacylglycerol emulsion. Determined every 1 or 2 wk were blood pressure, body weight, respiratory rate, blood count, liver functions, albumin, transferrin, plasma lipids, free fatty acids (FFAs), and, at the end of each treatment period (weeks 4 and 8), plasma dicarboxylic acids and 3-OH-fatty acids. No differences were observed between the groups or within the groups between the two treatments with respect to either clinical safety and adverse event occurrence or laboratory assessments. Plasma dicarboxylic acids and 3-OH-fatty acids weresimilar and within normal range. No alteration of liver function occurred in any of the patients treated with the structured lipid emulsion, whereas two of the patients receiving long-chain triaclyglycerol emulsion developedabnormal liver function, which resolved after switching to the structured Lipid emulsion. In conclusion, structured triacylyglycerols containing bothmedium- and long-chain fatty acids appear to be safe and well tolerated ona long-term basis in patients on home parenteral nutrition, and it may be associated with possible reduction in liver dysfunction. Nutrition 2000;16:95-100. (C) Elsevier Science Inc. 2000.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:15:52