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Titolo:
Effects of repeated phencyclidine treatment on serotonin transporter in rat brain
Autore:
Hori, T; Abe, S; Baba, A; Suzuki, T; Shiraishi, H;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 280, anno: 2000,
pagine: 53 - 56
SICI:
0304-3940(20000211)280:1<53:EORPTO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; BEHAVIORS; 5-HT; PCP;
Keywords:
phencyclidine; stereotyped behavior; tolerance; serotonin transporter; paroxetine; rat brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Hori, T Univ Tsukuba, Inst Clin Med, Dept Psychiat, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki Japan3058575 5, Japan
Citazione:
T. Hori et al., "Effects of repeated phencyclidine treatment on serotonin transporter in rat brain", NEUROSCI L, 280(1), 2000, pp. 53-56

Abstract

Phencyclidine (PCP) is known to be an inhibitor of serotonin (5-MT) uptakeand to increase serotonergic activity. The development of tolerance to serotonergic stereotyped behaviors induced by repeated PCP treatment and changes of 5-HT transporters were examined. Backpedalling was significantly reduced in frequency following 14 days PCP treatment (7.5 mg/kg per day). Furthermore, repeated PCP treatment decreased the equilibrium dissociation constant (Kd) Of [H-3]paroxetine binding to 5-HT transporters in whole brain excluding the cerebellum without any change of maximum number of binding sites(B-max). Single treatment with PCP failed to change binding parameters. These results indicate that repeated PCP treatment causes tolerance in serotonergic stereotyped behavior and increases affinity of 5-HT trans porters for [H-3]paroxetine binding. The increased affinity of 5-HT transporters could represent compensatory responses to chronic inhibition of 5-HT uptake by PCP, (C) 2000 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:35:47