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Titolo:
Kappa opioid receptor immunoreactivity in the nucleus accumbens and caudate-putamen is primarily associated with synaptic vesicles in axons
Autore:
Meshul, CK; McGinty, JF;
Indirizzi:
Oregon Hlth Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 urosci, Portland, OR 97201 USA Oregon Hlth Sci Univ, Vet Affairs Med Ctr, Res Serv, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 s Serv, Portland, OR 97201 USA E Carolina Univ, Sch Med, Dept Anat & Cell Biol, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 ll Biol, Greenville, NC 27858 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 96, anno: 2000,
pagine: 91 - 99
SICI:
0306-4522(2000)96:1<91:KORIIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; BEHAVIORAL SENSITIZATION; IMMUNOHISTOCHEMICAL LOCALIZATION; GLUTAMATE RELEASE; RAT-BRAIN; COCAINE; DOPAMINE; AGONIST; INHIBITION; ACTIVATION;
Keywords:
opioid receptor; kappa opioid receptor; nucleus accumbens; immunocytochemistry; electron microscopy; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: McGinty, JF Med Univ S Carolina, Dept Physiol & Neurosci, 167 Ashley Ave,Suite 607, Charleston, SC 29425 USA Med Univ S Carolina 167 Ashley Ave,Suite607 Charleston SC USA 29425
Citazione:
C.K. Meshul e J.F. McGinty, "Kappa opioid receptor immunoreactivity in the nucleus accumbens and caudate-putamen is primarily associated with synaptic vesicles in axons", NEUROSCIENC, 96(1), 2000, pp. 91-99

Abstract

A rabbit polyclonal antiserum, raised against a C-terminal oligopeptide ofthe mouse kappa opioid receptor, was used to localize the cellular distribution of kappa receptors in the dorsal and ventral striatum of rats with light and electron microscopic immunocytochemistry. Prominent, diffuse kappa receptor immunoreactivity was present in the nucleus accumbens, particularly in the shell, ventral caudate-putamen and olfactory tubercle. The densityof receptor immunoreactivity decreased in more dorsal areas of the caudate-putamen. In contrast, neuronal cell bodies stained clearly in the dorsal endopiriform nucleus, claustrum and layer VI of the adjacent cerebral cortex. Observations at the electron microscopic level in the dorsomedial shell of the nucleus accumbens and caudate-putamen revealed that the kappa receptor immunoreactivity was predominantly located in axons, often associated with synaptic vesicles, remote from the terminal or preterminal area. The few terminals which were labeled made slightly more asymmetrical than symmetrical contacts and the percentage of asymmetrical contacts observed was greater in the caudate than in the accumbens. A small number of postsynaptic spines was labeled; most of them were contacted by asymmetrical terminals. No labeling was observed in dendritic shafts. Thus, the predominant localization of kappa receptor immunoreactivity in axons is consistent with its role as a major inhibitor of glutamate and dopamine release in the dorsal and ventral striatum. (C) 2000 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 02/06/20 alle ore 22:19:34