Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clinicopathologic study on prognostic markers in IgA nephropathy
Autore:
Mera, J; Uchida, S; Nagase, M;
Indirizzi:
Teikyo Univ, Sch Med, Itabashi Ku, Tokyo 1738605, Japan Teikyo Univ Tokyo Japan 1738605 h Med, Itabashi Ku, Tokyo 1738605, Japan
Titolo Testata:
NEPHRON
fascicolo: 2, volume: 84, anno: 2000,
pagine: 148 - 157
SICI:
0028-2766(200002)84:2<148:CSOPMI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM PROGNOSIS; NATURAL-HISTORY; MESANGIAL NEPHROPATHY; FOLLOW-UP; HISTOLOGICAL ALTERATIONS; PROGRESSIVE DISEASE; RENAL SURVIVAL; GLOMERULONEPHRITIS; PROTEINURIA; NEPHRITIS;
Keywords:
IgA nephropathy, prognostic markers; renal biopsy; nephrotic syndrome; glomerular sclerosis; tubulointerstitial lesion; crescent formation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Mera, J Teikyo Univ, Sch Med, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan Teikyo Univ 2-11-1 Kaga Tokyo Japan 1738605 Tokyo 1738605, Japan
Citazione:
J. Mera et al., "Clinicopathologic study on prognostic markers in IgA nephropathy", NEPHRON, 84(2), 2000, pp. 148-157

Abstract

Background/Aim: Few prognostic markers have found general acceptance in IgA nephropathy (IgAN), The aim of the present study was to search for significant predictor(s) at the time of biopsy. Methods: Fifty-five patients withIgAN undergoing evaluation and treatment at our institution were examined regarding clinicopathologic features at the time of renal biopsy and, if possible, at follow-up. Factors predictive of outcome were evaluated. Renal histopathology was quantified using a glomerulosclerosis index (GSI), a tubulointerstitial index (TII), and a crescent index (CI). Results: The serum creatinine concentration (S-Cr) showed positive correlations with proteinuria and serum total cholesterol concentration, as well as with histopathologic findings, Heavy proteinuria (greater than or equal to 3.0 g/24 h) was associated with higher S-Cr and greater severity of pathologic abnormalities than with milder proteinuria. At follow-up, 6 patients progressed to chronicrenal insufficiency, in whom the S-Cr increased by at least 50% to reach or exceed 1.5 mg/dl (132.6 mu mol/l). By univariate analysis, elevated GSI, TII, and S-Cr, presence of nephrotic syndrome, elevated CI, and elevated total cholesterol were found to be negative predictors, in descending order of odds ratio. In multivariate analysis, however, only TII independently predicted unfavorable outcome, Conclusion: Renal biopsy in IgAN may be the most powerful predictor for renal outcome; an advanced tubulointerstitial lesion is unfavorable, Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:21:43