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Titolo:
Exposure of normal monocyte-derived dendritic cells to human immunodeficiency virus type-1 particles leads to the induction of apoptosis in co-cultured CD4(+) as well as CD8(+) T cells
Autore:
Suzuki, S; Tobiume, M; Kameoka, M; Sato, K; Takahashi, TA; Mukai, T; Ikuta, K;
Indirizzi:
Osaka Univ, Microbial Dis Res Inst, Dept Virol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 t Virol, Suita, Osaka 5650871, Japan Hokkaido Univ, Inst Immunol Sci, Sect Serol, Sapporo, Hokkaido 0600815, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600815 oro, Hokkaido 0600815, Japan Univ Tokyo, Inst Med Sci, Dept Cell Proc, Minato Ku, Tokyo 1080071, Japan Univ Tokyo Tokyo Japan 1080071 ell Proc, Minato Ku, Tokyo 1080071, Japan
Titolo Testata:
MICROBIOLOGY AND IMMUNOLOGY
fascicolo: 2, volume: 44, anno: 2000,
pagine: 111 - 121
SICI:
0385-5600(2000)44:2<111:EONMDC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION-INDUCED APOPTOSIS; EPIDERMAL LANGERHANS CELLS; HIV-INFECTED INDIVIDUALS; PERIPHERAL-BLOOD; CROSS-LINKING; POSSIBLE MECHANISM; AIDS PATHOGENESIS; LYMPHOID-TISSUE; FAS LIGAND; VIRAL LOAD;
Keywords:
HIV-1; dendritic cell; apoptosis; cell activation; pathogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Ikuta, K Osaka Univ, Microbial Dis Res Inst, Dept Virol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
S. Suzuki et al., "Exposure of normal monocyte-derived dendritic cells to human immunodeficiency virus type-1 particles leads to the induction of apoptosis in co-cultured CD4(+) as well as CD8(+) T cells", MICROB IMMU, 44(2), 2000, pp. 111-121

Abstract

The depletion of immune T cells by human immunodeficiency virus type-1 (HIV-1) infection is a major mechanism involved in the pathogenesis of AIDS. Here, we examined a possible effector function of blood monocyte-derived dendritic cells (DCs) to induce apoptosis in bystander CD4(+) and CD8(+) T cells. The DCs were generated by culturing monocytes in the presence of granulocyte-macrophage colony-stimulating factor and interleukin-4, The DCs exposed to HIV-1 particles were co-cultured with healthy donor-derived blood T cells at a ratio of 1:20, Analyses by percent cell mortality, staining with propidium iodide and reactivity with Annexin V revealed the induction of apoptosis in both CD4(+) and CD8(+) target T cells. Further, this apoptosis occurred without stimulation with mitogens when the cell cycle of target T cells shifted from G(0) to G(1), probably due to the mitogenic effect of theDCs, Thus, induction of apoptosis in both CD4(+) and CD8(+) T cells occurred via interaction with DCs adsorbed with HIV-1 particles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:45:49