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Titolo:
Association of plasminogen activator inhibitor-1 4G/4G genotype and type 2diabetic nephropathy in Chinese patients
Autore:
Wong, TYH; Poon, P; Szeto, CC; Chan, JCN; Li, PKT;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong Chinese Univ Hong Kong Shatin Hong Kong & Therapeut, Shatin, Hong Kong
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 2, volume: 57, anno: 2000,
pagine: 632 - 638
SICI:
0085-2538(200002)57:2<632:AOPAI4>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; PAI-1 GENE; CIRCULATING LEVELS; POLYMORPHISM; PROMOTER; RETINOPATHY; MELLITUS; DISEASE; CELLS; NIDDM;
Keywords:
type 2 diabetes mellitus; PAI-1 gene; angiotensin converting enzyme gene; gene polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Li, PKT Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong Chinese Univ Hong Kong Shatin Hong Kong peut, Shatin, Hong Kong
Citazione:
T.Y.H. Wong et al., "Association of plasminogen activator inhibitor-1 4G/4G genotype and type 2diabetic nephropathy in Chinese patients", KIDNEY INT, 57(2), 2000, pp. 632-638

Abstract

Background Plasminogen activator inhibitor-1 (PAI-1) is a key regulator offibrinolytic pathway and extracellular matrix (ECM) turnover. Because diabetic nephropathy is characterized by the presence of basement membrane thickening and mesangial expansion, we examined the role of PAI-1 gene polymorphisms in the development of type 2 diabetic nephropathy. Evidence also suggested that the PA/plasmin system and the renin-angiotensin system (RAS) interact together to affect the risk of fibrosis and thrombosis. Hence, we also studied the synergistic effect between PAI-1 and angiotensin-converting enzyme (ACE) gene polymorphisms. Methods. The PAI-1 and ACE (D/I) gene polymorphisms were examined in a cohort of Chinese type 2 diabetic patients who had diabetes for an average of 14 years. These patients were sex and age matched. Group A (N = 46) consisted of patients without diabetic nephropathy (normoalbuminuric with creatinine <120 mu mol/L), and group B (N = 95) was with diabetic nephropathy (withalbuminuria or renal impairment, including patients on dialysis). Results. Patients with type 2 diabetic nephropathy had a higher frequency of PAI-1 (4G/4G) genotypes than those without nephropathy [4G/4G:4G/5G:5G/5G = 41:38:21 (%) vs. 15:65:20(%), P = 0.005]. Diabetic patients with coexistence of PAI-1 4C/4G genotype and ACE D alleles had a higher incidence of diabetic nephropathy (22 vs. 7 %, P = 0.012) than those with other combinations of genotypes. Multivariate logistic regression analysis showed that PAI-1 4G/4G (P = 0.01) and the prevalence of hypertension (P < 0.0001) are independent risk factors of development of type 2 diabetic nephropathy. Conclusions. These results suggest that the PAI-1 4G/4G genotype is associated with an increased risk for type 2 diabetic nephropathy in Chinese patients, which is an independent risk factor for the development of nephropathy. The PAI-1 4G/4G genotype also exhibits a synergistic effect with the ACED allele on development of diabetic nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:42:32