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Titolo:
Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques
Autore:
Comi, G; Rovaris, M; Leocani, L; Martinelli, V; Filippi, M;
Indirizzi:
Univ Milan, Osped San Raffaele, Dept Neurosci, Inst Sci, I-20132 Milan, Italy Univ Milan Milan Italy I-20132 Neurosci, Inst Sci, I-20132 Milan, Italy
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
, volume: 172, anno: 2000, supplemento:, 1
pagine: S63 - S66
SICI:
0022-510X(20000115)172:<S63:AOTDOT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPEARING WHITE-MATTER; MRI LESION LOAD; MULTIPLE-SCLEROSIS; SPIN-ECHO; QUANTITATIVE ASSESSMENT; HYPOINTENSE LESIONS; AXONAL DAMAGE; PATHOLOGY; PATTERNS; DISEASE;
Keywords:
multiple sclerosis; magnetic resonance imaging; cognitive functions; frontal lobe; magnetization transfer imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Comi, G Univ Milan, Osped San Raffaele, Dept Neurosci, Inst Sci, Via Olgettina 60,I-20132 Milan, Italy Univ Milan Via Olgettina 60 Milan Italy I-20132 0132 Milan, Italy
Citazione:
G. Comi et al., "Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques", J NEUR SCI, 172, 2000, pp. S63-S66

Abstract

The pattern of mental dysfunction in multiple sclerosis (MS) is characteristic of the so-called subcortical dementia. Cognitive dysfunction results predominantly by the disruption of communication among cortical and subcortical areas, as a consequence of the white matter damage. As expected, studies with conventional magnetic resonance imaging (MRI) demonstrated that cognitive impairment in MS patients is related to the lesion burden, although the strength of this correlation is weak. This can be partially explained bythe poor pathological specificity of conventional MRI techniques and by the invisible damage in the normal-appearing white matter (NAWM). Recent studies using non-conventional MRI techniques with a higher specificity for theheterogeneous substrates of MS pathology, such as the assessment of hypointense lesion load on T1-weighted scans and the measurement of;he magnetization transfer ratio (MTR) of whole brain, MS lesions and NAWM, support this interpretation. Other factors, such as the site of MS lesions and the presence of active inflammation, also seem to play an important role. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:31:33