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Titolo:
Modulation of gastrointestinal afferent sensitivity by a novel substitutedbenzamide (ecabapide)
Autore:
Jiang, W; Grundy, D;
Indirizzi:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TN S Yorkshire, England
Titolo Testata:
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
fascicolo: 2-3, volume: 78, anno: 2000,
pagine: 99 - 108
SICI:
0165-1838(20000114)78:2-3<99:MOGASB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROKINETIC AGENT; DQ-2511; RAT; DISORDERS; CISAPRIDE; MOTILITY;
Keywords:
ecabapide; CCK8; 2Me-5-HT; gastrointestinal afferent fibre; ischaemia; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Jiang, W Univ Sheffield, Dept Biomed Sci, Western Bank, Sheffield S10 2TN,S Yorkshire, England Univ Sheffield Western Bank Sheffield S Yorkshire England S10 2TN
Citazione:
W. Jiang e D. Grundy, "Modulation of gastrointestinal afferent sensitivity by a novel substitutedbenzamide (ecabapide)", J AUTON NER, 78(2-3), 2000, pp. 99-108

Abstract

The effects of ecabapide, a novel substituted benzamide compound (3-[2-(3,3-dimethoxyphenyl)ethylcarbamoylmethyl]methylbenzamide) that has gastrointestinal prokinetic action, were examined on the discharge of extrinsic afferent nerves supplying the stomach and jejunum in anaesthetized rats. Ecabapide (60 and 180 mu g kg(-1), iv) had no effect on the baseline discharge of vagal gastric distension-sensitive afferents or the stimulus-response profile to gastric distension. Ecabapide also had no effect on either spontaneous jejunal mesenteric afferent nerve discharge or responses to intestinal distension. Ecabapide (180 mu g kg(-1)) significantly inhibited the maximum discharge of jejunal afferents induced by cholecystokinin (CCK8; 50 pmol, iv), whereas it failed to inhibit the excitatory action of 2-methyl-5-hydroxytryptamine (2Me-5-HT; 10 mu g, iv), a selective 5-HT3 receptor agonist. A model of acute focal intestinal ischaemia was used to evaluate the actions of ecabapide on the discharge of activated jejunal afferents. Ischaemia produced a substantial increase in afferent discharge which was reproducible when the duration of ischaemia was limited to less than 10 min and repeated every 15 min. Ecabapide at doses of 60 and 180 mu g kg(-1) significantly reduced ischaemia-induced increases in afferent discharge. In addition to its therapeutic efficacy as a gastrointestinal prokinetic agent, these findingsshow also that ecabapide may also have an inhibitory action on the discharge of intestinal afferents activated by ischaemia. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:24:36