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Titolo:
Detecting drug effects on short-term memory function using a combined delayed matching and non-matching to position task
Autore:
Pache, DM; Sewell, RDE; Spencer, PSJ;
Indirizzi:
Cardiff Univ, Welsh Sch Pharm, Mechanisms Drug Act Grp, Cardiff CF1 3XF, SGlam, Wales Cardiff Univ Cardiff S Glam Wales CF1 3XF , Cardiff CF1 3XF, SGlam, Wales
Titolo Testata:
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
fascicolo: 4, volume: 41, anno: 1999,
pagine: 135 - 141
SICI:
1056-8719(199908)41:4<135:DDEOSM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORKING-MEMORY; RATS; SCOPOLAMINE; 8-OH-DPAT;
Keywords:
delayed non-matching to position; delayed matching to position; short-term memory function; scopolamine; 8-OH-DPAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Pache, DM Cardiff Univ, Welsh Sch Pharm, Mechanisms Drug Act Grp, Redwood Bldg,King Edward 7 Ave,Cathays Pk, Cardiff CF1 3XF, S Glam, Wales Cardiff Univ Redwood Bldg,King Edward 7 Ave,Cathays Pk Cardiff S Glam Wales CF1 3XF
Citazione:
D.M. Pache et al., "Detecting drug effects on short-term memory function using a combined delayed matching and non-matching to position task", J PHARM TOX, 41(4), 1999, pp. 135-141

Abstract

Operant delayed non-matching-to-position (DNMTP) and delayed matching-to-position (DMTP) have become standard techniques to investigate drug effects on short-term memory function in rats. However, these two tasks are normally conducted in isolation. Using two standard drugs, the 5HT(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), and the muscarinic antagonist scopolamine, this study looked at a two-choice operant task that essentially involved a mixed DNMTP/DMTP paradigm. Thus, DNMTP trials were interspersed with DMTP trials in a random sequence for the duration of a session. 8-OH-DPAT (0.03 mg/kg) slightly but significantly improved response accuracy in a delay-dependent fashion during DMTP but not DNMTP trials. The highest dose of 8-OH-DPAT (0.1 mg/kg) impaired accuracy during DNMTP trials independent of delay and had no significant effect during DMTP trials. Scopolamine (0.1 mg/kg) produced delay-dependent deficits in accuracy during DMTP trials but delay-independent impairments during DNMTP trials. Because both 8-OH-DPAT and scopolamine produced delay-dependent: effects with DMTP trials types and either had no effect (8-OH-DPAT) or produced delay-independent impairments (scopolamine) during DNMTP trials types, it is suggested that DMTP trials had a greater dependence on short-term working memory function than DNMTP trials that probably relied more on positional (mediating) strategies for solving the task. Therefore, we believe that this mixed DNMTP/DMTP task offers greater potential for more reliable and discerning interpretation of data regarding short-term memory function in rodents than either of the paradigms performed in isolation. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 01:44:11