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Titolo:
Tea and tea polyphenols in cancer prevention
Autore:
Yang, CS; Chung, JY; Yang, GY; Chhabra, SK; Lee, MJ;
Indirizzi:
Rutgers State Univ, Coll Pharm, Canc Res Lab, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Lab, Piscataway, NJ 08854 USA
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 2, volume: 130, anno: 2000, supplemento:, S
pagine: 472S - 478S
SICI:
0022-3166(200002)130:2<472S:TATPIC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRINKING GREEN TEA; BLACK TEA; A/J MICE; LUNG TUMORIGENESIS; SKH-1 MICE; (-)-EPIGALLOCATECHIN GALLATE; EPIGALLOCATECHIN GALLATE; IMPORTANT CONSTITUENT; PROSPECTIVE COHORT; GROWTH-INHIBITION;
Keywords:
tea; polyphenols; cancer chemoprevention; animal models; cancer cell lines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, CS Rutgers State Univ, Coll Pharm, Canc Res Lab, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 cataway, NJ 08854 USA
Citazione:
C.S. Yang et al., "Tea and tea polyphenols in cancer prevention", J NUTR, 130(2), 2000, pp. 472S-478S

Abstract

The inhibitory action of tea (Camellia sinensis) and tea components against cancer formation has been demonstrated in different animal models involving different organ sites in many laboratories. The possible preventive activity of tea against cancer in humans, however, is not clear. A critical question is whether the information obtained from animal studies is applicableto humans because of possible species differences or the difference in thequantity of tea used in animal studies and that consumed by humans. This article will discuss the results from animal studies and possible cancer inhibitory mechanisms that might be applicable to human cancer prevention. To provide a basis for more quantitative analyses of the effect of tea on carcinogenesis, the levels of tea polyphenols in blood, urine and tissue samples have been analyzed, and the pharmacokinetic properties of tea polyphenolsstudied. Studies with cell lines have demonstrated that tea polyphenols affect signal transduction pathways, inhibit cell proliferation and induce apoptosis, but the effective concentrations are usually much higher than those observed in blood and tissues. More mechanistic studies in these areas will help us to understand the inhibitory action of tea against carcinogenesis and provide background for evaluating the effects of tea consumption on human carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:30:25