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Titolo:
Iodinated free fatty acid and Tl-201 uptake in chronically hypoperfused myocardium: Histologic correlation study
Autore:
Kudoh, T; Tadamura, E; Tamaki, N; Hattori, N; Inubushi, M; Kubo, S; Magata, Y; Nishimura, K; Matsuda, K; Konishi, J;
Indirizzi:
Kyoto Univ, Sch Med, Dept Nucl Med & Diagnost Imaging, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 Nucl Med & Diagnost Imaging, Kyoto 606, Japan Kyoto Univ, Sch Med, Dept Cardiovasc Surg, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 h Med, Dept Cardiovasc Surg, Kyoto 606, Japan Hokkaido Univ, Sch Med, Dept Nucl Med, Sapporo, Hokkaido, Japan Hokkaido Univ Sapporo Hokkaido Japan Nucl Med, Sapporo, Hokkaido, Japan
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 41, anno: 2000,
pagine: 293 - 296
SICI:
0161-5505(200002)41:2<293:IFFAAT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIABILITY; MARKER;
Keywords:
I-123-BMIPP; Tl-201; myocardial fibrosis; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Kudoh, T Kinki Univ, Dept Radiol, 377-2 Ohno Higashi, Osaka 5898511, JapanKinki Univ 377-2 Ohno Higashi Osaka Japan 5898511 5898511, Japan
Citazione:
T. Kudoh et al., "Iodinated free fatty acid and Tl-201 uptake in chronically hypoperfused myocardium: Histologic correlation study", J NUCL MED, 41(2), 2000, pp. 293-296

Abstract

I-123-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) is a tracer for the evaluation of ischemic heart disease. The purpose of this study was to assess the relationship between I-123-BMIPP uptake and myocardial fibrosis. Methods: Fifteen patients who underwent cardiac surgery were examined by imaging with Tl-201 and I-123-BMIPP, and histologic specimens were taken during surgery. The relative uptake of Tl-201 (%Tl) and that of I-123-BMIPP (%BMIPP) were calculated. The percentage of fibrosis (%fibrosis) was analyzed with the specimen. Results: %Tl correlated strongly with %fibrosis (r = -0.94; P < 0.001). %BMIPP also correlated significantly with %fibrosis(r = -0.88; P < 0.001), but the change in %BMIPP looked biphasic. In the category of only mild fibrosis, %BMIPP showed a steep decrease. I-123-BMIPP-Tl-201 mismatch was found only for fibrosis <20%. Conclusion: I-123-BMIPP gave specific information about metabolic changes that occurred in ischemic myocardium without severe fibrotic changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:00:44