Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PET quantification of 5-HT2A receptors in the human brain: A constant infusion paradigm with [F-18]altanserin
Autore:
van Dyck, CH; Tan, PZ; Baldwin, RM; Amici, LA; Garg, PK; Ng, CK; Soufer, R; Charney, DS; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 , Dept Psychiat, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Diagnost Radiol, New Haven, CT 06510 USA W Haven Vet Affairs Med Ctr, W Haven, CT USA W Haven Vet Affairs Med Ctr W Haven CT USA airs Med Ctr, W Haven, CT USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 41, anno: 2000,
pagine: 234 - 241
SICI:
0161-5505(200002)41:2<234:PQO5RI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; LIVING HUMAN-BRAIN; F-18 ALTANSERIN; BINDING-SITES; SEROTONIN RECEPTORS; REDUCED BINDING; ALZHEIMER-TYPE; AGE; LOCALIZATION; RADIOLIGAND;
Keywords:
[F-18]altanserin; 5-HT2A receptor; serotonin; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: van Dyck, CH Yale Univ, Sch Med, Dept Psychiat, CB 2041,333 Cedar St, New Haven, CT 06510 USA Yale Univ CB 2041,333 Cedar St New Haven CT USA 06510 510 USA
Citazione:
C.H. van Dyck et al., "PET quantification of 5-HT2A receptors in the human brain: A constant infusion paradigm with [F-18]altanserin", J NUCL MED, 41(2), 2000, pp. 234-241

Abstract

[F-18]altanserin has been used to label serotonin 5-HT2A receptors, which are believed to be important in the pathophysiology of schizophrenia and depression. The purpose of this study was to test the feasibility of a constant infusion paradigm for equilibrium modeling of [F-18]altanserin with PET. Kinetic modeling with [F-18]altanserin may be hampered by the presence of lipophilic radiometabolites observed in plasma after intravenous administration. Methods: Eight healthy volunteers were injected with [F-18]altanserinas a bolus (208 +/- 9 MBq [5.62 +/- 0.25 mCi]) plus constant infusion (65 /- 3 MBq/h [1.76 +/- 0.08 mCi/h]) ranging from 555 to 626 min (615 +/- 24 min) after injection. PET acquisitions (10-20 min) and Venous blood sampling were performed every 30-60 min throughout the infusion period. Results: Linear regression analysis revealed that time-activity curves for both brainactivity and plasma [F-18]altanserin and metabolite concentrations stabilized after about 6 h. This permitted equilibrium modeling and estimation of V-3' (ratio of specific uptake [cortical-cerebellar] to total plasma parentconcentration after 6 h). Values of V-3' ranged from 1.57 +/- 0.38 for anterior cingulate cortex to 1.02 +/- 0.39 for frontal cortex. The binding potential V-3 (ratio of specific uptake to free plasma parent concentration after 6 h, using group mean f(1)) was also calculated and ranged from 169 +/-41 for anterior cingulate cortex to 110 +/- 42 for frontal cortex. From 6 h onward, the rate of change for V-3' and V-3 was only 1.11 +/- 1.69 %/h. Conclusion: These results demonstrate the feasibility of equilibrium imagingwith [F-18]altanserin over more than 5 radioactive half-lives and suggest a method to overcome difficulties associated with lipophilic radiolabeled metabolites. The stability in V-3 and V-3' once equilibrium is achieved suggests that a single PET acquisition obtained at 6 h may provide a reasonablemeasure of 5-HT2A receptor density.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:00:32