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Titolo:
Oligodendrocytes and the control of myelination in vivo: New insights fromthe rat anterior medullary velum
Autore:
Butt, AM; Berry, M;
Indirizzi:
Univ London Kings Coll, Neural Damage & Repair Grp, Ctr Neurosci, GKT Sch Biomed Sci, London SE1 9RT, England Univ London Kings Coll London EnglandSE1 9RT i, London SE1 9RT, England
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 4, volume: 59, anno: 2000,
pagine: 477 - 488
SICI:
0360-4012(20000215)59:4<477:OATCOM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; PDGF-ALPHA-RECEPTOR; IMMUNO-ULTRASTRUCTURAL LOCALIZATION; PROTEIN GENE-EXPRESSION; CENTRAL-NERVOUS-SYSTEM; O2A PROGENITOR CELLS; OPTIC-NERVE; ADULT-RAT; BASIC-PROTEIN; GLIAL-CELLS;
Keywords:
oligodendrocyte; myelin; anterior medullary velum; brain, rat; axon; node of Ranvier; NG2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Butt, AM Univ London Kings Coll, Neural Damage & Repair Grp, Ctr Neurosci,GKT Sch Biomed Sci, Guys Campus,London Bridge, London SE1 9RT, England Univ London Kings Coll Guys Campus,London Bridge London England SE1 9RT
Citazione:
A.M. Butt e M. Berry, "Oligodendrocytes and the control of myelination in vivo: New insights fromthe rat anterior medullary velum", J NEUROSC R, 59(4), 2000, pp. 477-488

Abstract

The rat anterior medullary velum (AMV) is representative of the brain and spinal cord, overall, and provides an almost two-dimensional preparation for investigating axon-glial interactions in vivo. Here, we review some of our findings on axon-oligodendrocyte unit relations in our adult, development, and injury paradigms: (1) adult oligodendrocytes are phenotypically heterogeneous, conforming to Del Rio Hortega's types I-IV, whereby differences in oligodendrocyte morphology, metabolism, myelin sheath radial and longitudinal dimensions, and biochemistry correlate with the diameters of axons in the unit; (2) oligodendrocytes derive from a common premyelinating oligodendrocyte phenotype, and divergence of types I-IV is related to the age they emerge and the presumptive diameter of axons in the unit; (3) during myelination, axon-oligodendrocyte units progress through a sequence of maturationphases, related to axon contact, ensheathment, establishment of internodalmyelin sheaths, and finally the radial growth and compaction of the myelinsheath; (4) we provide direct in vivo evidence that platelet-derived growth factor-AA (PDGF-AA), fibroblast growth factor (FGF-2), and insulin-like growth factor-1 (IGF-I) differentially regulate these events, by injecting the growth factors into the cerebrospinal fluid of neonatal rat pups; (5) inlesioned adult AMV, transected central nervous system (CNS) axons regenerate through the putatively inhibitory environment of the glial scar, but remyelination by oligodendrocytes is incomplete, indicating that axon-oligodendrocyte interactions are defective; and (6) in the adult AMV, cells expressing the NG2 chondroitin sulphate have a presumptive adult oligodendrocyte progenitor antigenic phenotype, but are highly complex cells and send processes to contact axolemma at nodes of Ranvier, suggesting they subserve a specific perinodal function. Thus, axons and oligodendrocyte lineage cells form interdependent functional units, but oligodendrocyte numbers, differentiation, phenotype divergence, and myelinogenesis are governed by axons in theunits, mediated by growth factors and contact-dependent signals. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:46:26