Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
An overview of salt absorption by the nephron
Autore:
Andreoli, TE;
Indirizzi:
Univ Arkansas, Coll Med, Dept Internal Med, Little Rock, AR 72205 USA UnivArkansas Little Rock AR USA 72205 nal Med, Little Rock, AR 72205 USA
Titolo Testata:
JOURNAL OF NEPHROLOGY
, volume: 12, anno: 1999, supplemento:, 2
pagine: S3 - S15
SICI:
1121-8428(199907/08)12:<S3:AOOSAB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL CONVOLUTED TUBULE; RENAL BRUSH-BORDER; MEDULLARY COLLECTING DUCT; NA+-H+ EXCHANGER; CHLORIDE TRANSPORT; BASOLATERAL MEMBRANE; VOLUME ABSORPTION; FLUID ABSORPTION; PARS-RECTA; GLUCOSE-TRANSPORT;
Keywords:
nephron function; historical evolution of concepts concerning nephron function; Na plus absorption; K plus secretion; H plus secretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Andreoli, TE Univ Arkansas, Coll Med, Dept Internal Med, 4301 W Markham,Slot 640, Little Rock, AR 72205 USA Univ Arkansas 4301 W Markham,Slot 640 Little Rock AR USA 72205
Citazione:
T.E. Andreoli, "An overview of salt absorption by the nephron", J NEPHROL, 12, 1999, pp. S3-S15

Abstract

The purpose of this brief commentary is to provide a description of how renal physiology, and more particularly, renal tubular physiology, has evolved over the past thirty years, since the occasion, obviously, is a celebration of the Thirtieth Course on Advances in Nephrology and Dialysis. My arguments will begin by quoting from Homer Smith's book, The Kidney, and mergingSmith's observations, which were integrative in the sense that they did not specify detail, with detailed incursions into tubular physiology, first at a cellular level and then at a molecular level. For convenience, the nephron is divided into four functional segments: the proximal nephron; the ascending limb; the distal nephron; and the collecting duct. Each of these carries out a specific function. The proximal nephron absorbs about two-thirdsof filtered sodium, without dissociating salt and water absorption. The thick ascending limb absorbs 25% of filtered Na+, but no water. The distal nephron absorbs 10% of filtered Na+ in close relation with K+ and, to some extent, H+ secretion. Finally, the collecting duct includes three kinds of cells: the cortical collecting duct, which is responsible not only for Na+ absorption and K+ secretion, but also for the bulk of the absorption of freewater; the outer medullary collecting duct (OMCD), which is largely responsible for the final steep drop in urine pH which occurs between cortex and papilla; and the inner medullary collecting duct (IMCD), whose major function is the final absorption of approximately 5% of filtered Na+.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:05:50