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Titolo:
Antisense peptide interactions studied by electrospray ionization mass spectrometry
Autore:
Madhusudanan, KP; Katti, SB; Haq, W; Misra, PK;
Indirizzi:
Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India Cent Drug Res Inst Lucknow Uttar Pradesh India 226001 ttar Pradesh, India
Titolo Testata:
JOURNAL OF MASS SPECTROMETRY
fascicolo: 2, volume: 35, anno: 2000,
pagine: 237 - 241
SICI:
1076-5174(200002)35:2<237:APISBE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONCOVALENT ASSOCIATIONS; COMPLEXES; CYCLODEXTRIN; COMPLEMENTARY; PROTEINS; RECEPTOR; DESIGN;
Keywords:
antisense peptides; electrospray ionization mass spectrometry; non-covalent complexes; heterodimers; interactions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Madhusudanan, KP Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India Cent Drug Res Inst Lucknow Uttar Pradesh India 226001 ia
Citazione:
K.P. Madhusudanan et al., "Antisense peptide interactions studied by electrospray ionization mass spectrometry", J MASS SPEC, 35(2), 2000, pp. 237-241

Abstract

Non-covalent interactions between met- and leu-enkephalins and their antisense peptides were studied by electrospray ionization mass spectrometry. Mixtures of sense and antisense peptides gave both the corresponding homodimers and heterodimers, The relative abundance ratios of the heterodimer to that of the homodimer of the sense peptide and the relative stability constants of the heterodimers were compared with the corresponding values from mixtures of the sense peptides and a control peptide. The results show that there is a preferential interaction between the sense and antisense peptides compared with that between the sense and control peptides. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 01:09:19