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Titolo:
Acute production of vascular superoxide by angiotensin II but not by catecholamines
Autore:
Kawazoe, T; Kosaka, H; Yoneyama, H; Hata, Y;
Indirizzi:
Kagawa Med Univ, Dept Physiol 2, Kagawa 7610793, Japan Kagawa Med Univ Kagawa Japan 7610793 pt Physiol 2, Kagawa 7610793, Japan Kagawa Med Univ, Dept Plast Surg, Kagawa 7610793, Japan Kagawa Med Univ Kagawa Japan 7610793 t Plast Surg, Kagawa 7610793, Japan
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 2, volume: 18, anno: 2000,
pagine: 179 - 185
SICI:
0263-6352(200002)18:2<179:APOVSB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; NADPH OXIDASE ACTIVITY; HYPERTENSION; HYPERTROPHY; RAT; CONTRACTIONS; ENDOTHELIN-1; GENERATION; H2O2;
Keywords:
angiotensin II; superoxide; hypertension; aortic ring; norepinephrine; isometric tension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kosaka, H Kagawa Med Univ, Dept Physiol 2, 1750-1 Ikenobe, Kagawa 7610793,Japan Kagawa Med Univ 1750-1 Ikenobe Kagawa Japan 7610793 0793, Japan
Citazione:
T. Kawazoe et al., "Acute production of vascular superoxide by angiotensin II but not by catecholamines", J HYPERTENS, 18(2), 2000, pp. 179-185

Abstract

Objective To determine whether vascular superoxide is rapidly released by angiotensin II and is involved in vascular contraction. Design The effect of superoxide dismutase (SOD) on angiotensin II induced elevation of mean arterial blood pressure was measured. Subsequently, acuteproduction of vascular superoxide by angiotensin II and its effect on isometric tension were measured in rat aortic rings, The effects of catecholamines were concomitantly measured,Methods and results The acute presser effects of angiotensin II were significantly reduced when rats were pretreated intravenously with SOD, When angiotensin II was added on aortic segments in the presence of Cypridina luciferin analog, immediate elevations of chemiluminescence were observed which were inhibited by SOD. Furthermore, angiotensin II-induced elevations of isometric tension in aortic rings were significantly reduced by SOD. The effects of epinephrine and norepinephrine were concomitantly measured and were not significant. Conclusions The acute superoxide producing effect is likely to be specificto angiotensin II, because such a significant modification of the effects was not observed for catecholamines. Our results suggest that angiotensin II causes acute vascular superoxide production, which may be involved in theacute presser effects. J Hypertens 2000, 18:179-185 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:53:54