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Titolo:
Superoxide dismutase activity in children with chronic liver diseases
Autore:
Broide, E; Klinowski, E; Koukoulis, G; Hadzic, N; Portmann, B; Baker, A; Scapa, E; Mieli-Vergani, G;
Indirizzi:
Tel Aviv Univ, Inst Gastroenterol, Assaf Harofeh Med Ctr, Sackler Sch Med,IL-70300 Zerifin, Israel Tel Aviv Univ Zerifin Israel IL-70300 r Sch Med,IL-70300 Zerifin, Israel Tel Aviv Univ, Gen Intens Care Unit, Assaf Harofeh Med Ctr, Sackler Sch Med, IL-70300 Zerifin, Israel Tel Aviv Univ Zerifin Israel IL-70300 Sch Med, IL-70300 Zerifin, Israel Univ London Kings Coll Hosp, Dept Child Hlth, London, England Univ London Kings Coll Hosp London England Child Hlth, London, England Univ London Kings Coll Hosp, Inst Liver Studies, London, England Univ London Kings Coll Hosp London England ver Studies, London, England
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 2, volume: 32, anno: 2000,
pagine: 188 - 192
SICI:
0168-8278(200002)32:2<188:SDAICW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRAHEPATIC BILIARY ATRESIA; FREE-RADICALS; NEONATAL HEPATITIS; NITRIC-OXIDE; RAT-LIVER; INJURY; INVOLVEMENT; ANTIOXIDANTS; MITOCHONDRIA; MECHANISMS;
Keywords:
children; cholestastic liver diseases; chronic liver diseases; portal vein thrombosis; reactive oxygen intermediates; superoxide dismutase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Broide, E Tel Aviv Univ, Inst Gastroenterol, Assaf Harofeh Med Ctr, Sackler Sch Med,IL-70300 Zerifin, Israel Tel Aviv Univ Zerifin Israel IL-70300 IL-70300 Zerifin, Israel
Citazione:
E. Broide et al., "Superoxide dismutase activity in children with chronic liver diseases", J HEPATOL, 32(2), 2000, pp. 188-192

Abstract

Background/Aims: Liver disease in infancy has multiple etiologies. As reactive oxygen intermediates are involved in several types of tissue damage, we have investigated whether different forms of liver disease in infancy areassociated with increased free radical generation, using an indirect approach in which superoxide dismutase (a free radical scavenger) activity is determined in the liver tissue. Methods: A total of 48 liver biopsies performed at diagnosis were evaluated retrospectively. Nine infants had biliary atresia, eight Alagille syndrome, seven alpha 1-antitrypsin deficiency and 12 cryptogenic hepatitis. As controls we studied 12 biopsies with normal histology obtained from seven children with portal vein thrombosis and five children who underwent biopsy for management reason bat had no liver disease. Superoxide dismutase activityin liver biopsy specimens was measured using the cytochrome C method by spectrophotometry and expressed as U SOD/mg protein. Results: Superoxide dismutase activity was significantly increased in biliary atresia (1.25 +/- 0.56 U SOD/mg protein, p < 0.0001) and Alagille syndrome (1.31 +/- 0.56 U SOD/mg protein, p < 0.0001) as compared with alpha 1-antitrypsin deficiency (0.75 +/- 0.3 U SOD/mg protein), neonatal hepatitis (0.72 +/- 0.37 U. SOD/mg protein) and normal controls (0.4 +/- 0.7 U. SOD/mgprotein). The highest level of SOD activity was found, however, in controlchildren with portal vein thrombosis (2.09 +/- 0.96 U SOD/mg protein; p < 0.0001 as compared to the other groups). Conclusion: Superoxide dismutase, a key enzyme in free radical protection,is increased significantly in the liver tissue of infants with cholestaticliver disease due to bile duct damage and in children,vith portal vein thrombosis, suggesting that products of free radical reactions are involved inthe pathogenesis of these disorders.

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Documento generato il 28/09/20 alle ore 17:05:25