Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Changes in autonomic activity and ventricular repolarization
Autore:
Shusterman, V; Beigel, A; Shah, SI; Aysin, B; Weiss, R; Gottipaty, VK; Schwartzman, D; Anderson, KP;
Indirizzi:
Univ Pittsburgh Hlth Syst, Cardiovasc Inst, Cardiac Electrophysiol Program, Pittsburgh, PA USA Univ Pittsburgh Hlth Syst Pittsburgh PA USA Program, Pittsburgh, PA USA
Titolo Testata:
JOURNAL OF ELECTROCARDIOLOGY
, volume: 32, anno: 1999, supplemento:, S
pagine: 185 - 192
SICI:
0022-0736(1999)32:<185:CIAAAV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION-RECOVERY INTERVALS; HEART-RATE-VARIABILITY; CORONARY-ARTERY DISEASE; FAILING HUMAN-HEART; TACHYCARDIA; ELECTROGRAMS; INTERVENTIONS; ARRHYTHMIAS; INDUCTION; INVIVO;
Keywords:
autonomic activity; ventricular repolarization; body surface potential mapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Shusterman, V Presbyterian Univ Hosp, CVI UPHS, Cardiac Electrophysiol Program, Rm B535,200 Lothrop St, Pittsburgh, PA 15213 USA Presbyterian Univ Hosp Rm B535,200 Lothrop St Pittsburgh PA USA 15213
Citazione:
V. Shusterman et al., "Changes in autonomic activity and ventricular repolarization", J ELCARDIOL, 32, 1999, pp. 185-192

Abstract

An increase in sympathetic activity, manifested by shortening of RR intervals (RRi) and changes in RRL variability, precedes and possibly triggers ventricular tachyarrhythmias (VTAs) by altering repolarization. We examined the effects of autonomic activity on the projection of repolarization as detected by body surface potential maps (BSPMs). We recorded 32 lead/192-pointBSPMs during passive head-up tilt, tilt + infusion of isoproterenol, rapidatrial pacing, and atrial pacing + infusion of isoproterenol. Changes in QT; recovery time; activation-recovery interval (ARi); T-wave amplitude; andQT, QRST, and ST integrals and their dispersion were analyzed. Autonomic effects on sinus node were inferred from the Fourier transform-derived low and high frequency powers of RRi variability. Patients were divided into those with (SHD) and without structural heart disease (NSHD). Heart rate increased, whereas QT interval and ARi declined with tilt in both groups. RRi variability indices of sympathetic activity increased in NSHD but did not change in SHD. T-wave amplitudes declined in NSHD but did not change in SHD, suggesting altered responsiveness of ventricular repolarization to autonomicstimulation. Tilt and rapid atrial pacing during infusion of isoproterenolresulted in a paradoxical increase in T-wave amplitudes in some patients, similar to that observed before the onset of spontaneous arrhythmias. We conclude that altering autonomic activity by head-up tilt and/or infusion of sympathomimetic agents results in significant changes in the body surface projection of cardiac repolarization, which differ in patients with SHD fromthose without SHD. Similar paradoxical changes in the T-wave amplitude have been observed before the onset of spontaneous VTA, suggesting that abnormal response of repolarization to autonomic stimulation predisposes to arrhythmogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:25:40