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Titolo:
Functional cis-heterodimers of N- and R-cadherins
Autore:
Shan, WS; Tanaka, H; Phillips, GR; Arndt, K; Yoshida, M; Colman, DR; Shapiro, L;
Indirizzi:
NYU, Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA NYU New York NY USA 10029 ys, Struct Biol Program, New York, NY 10029 USA NYU, Mt Sinai Sch Med, Dept Biochem & Mol Biol, New York, NY 10029 USA NYU New York NY USA 10029 Dept Biochem & Mol Biol, New York, NY 10029 USA NYU, Mt Sinai Sch Med, Program Cell Adhes, New York, NY 10029 USA NYU NewYork NY USA 10029 Med, Program Cell Adhes, New York, NY 10029 USA
Titolo Testata:
JOURNAL OF CELL BIOLOGY
fascicolo: 3, volume: 148, anno: 2000,
pagine: 579 - 590
SICI:
0021-9525(20000207)148:3<579:FCONAR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; CENTRAL-NERVOUS-SYSTEM; DIFFERENTIAL EXPRESSION; CYTOPLASMIC DOMAIN; COMPLEX-FORMATION; STRUCTURAL BASIS; VERTEBRATE CNS; FAMILY; REGION; BRAIN;
Keywords:
cadherins; cell adhesion; heterophilic binding; synaptic adhesion; dimerization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Shapiro, L NYU, Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, 1425 Madison Ave, New York, NY 10029 USA NYU 1425 Madison Ave New YorkNY USA 10029 w York, NY 10029 USA
Citazione:
W.S. Shan et al., "Functional cis-heterodimers of N- and R-cadherins", J CELL BIOL, 148(3), 2000, pp. 579-590

Abstract

Classical cadherins form parallel cis-dimers that emanate from a single cell surface. It is thought that the cis-dimeric form is active in cell-cell adhesion, whereas cadherin monomers are likely to be inactive. Currently, cis-dimers have been shown to exist only between cadherins of the same type. Here, we show the specific formation of cis-heterodimers between N- and R-cadherins. E-cadherin cannot participate in these complexes. Cells coexpressing N- and R-cadherins show hemophilic adhesion in which these proteins coassociate at cell-cell interfaces. We performed site-directed mutagenesis studies, the results of which sup-port the strand dimer model for cis-dimerization. Furthermore, we show that when N- and R-cadherins are coexpressed in neurons in vitro, the two cadherins colocalize at certain neural synapses, implying biological relevance for these complexes. The present study provides a novel paradigm for cadherin interaction whereby selective cis-heterodimer formation may generate new functional units to mediate cell-cell adhesion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:14:21