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Titolo:
Effects of ventilation on the surfactant system in sepsis-induced lung injury
Autore:
Malloy, JL; Veldhuizen, RAW; Lewis, JF;
Indirizzi:
Univ Western Ontario, St Josephs Hlth Ctr, Dept Med, Lawson Res Inst, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, St Josephs Hlth Ctr, Dept Physiol, Lawson Res Inst, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 88, anno: 2000,
pagine: 401 - 408
SICI:
8750-7587(200002)88:2<401:EOVOTS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; END-EXPIRATORY PRESSURE; MECHANICAL VENTILATION; PULMONARY SURFACTANT; EDEMA; SUBFRACTIONS; METABOLISM; BUBBLE;
Keywords:
ventilation-induced lung injury; lung collapse; positive-end expiratory pressure; aggregates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Malloy, JL Univ Western Ontario, St Josephs Hlth Ctr, Dept Med, Lawson ResInst, 268 Grosvenor St, London, ON N6A 4V2, Canada Univ Western Ontario 268 Grosvenor St London ON Canada N6A 4V2
Citazione:
J.L. Malloy et al., "Effects of ventilation on the surfactant system in sepsis-induced lung injury", J APP PHYSL, 88(2), 2000, pp. 401-408

Abstract

The present study examined the effects of mechanical ventilation, with or without positive end-expiratory pressure (PEEP), on the alveolar surfactantsystem in an animal model of sepsis-induced lung injury. Septic animals ventilated without PEEP had a significant deterioration in oxygenation compared with preventilated values (arterial PO2/inspired O-2 fraction 316 +/- 16vs. 151 +/- 14 Torr; P < 0.05). This was associated with a significantly lower percentage of the functional large aggregates (59 +/- 3 vs. 72 +/- 4%)along with a significantly reduced function (minimum surface tension 17.7 /- 1.8 vs. 11.8 +/- 3.8 mN/m) compared with nonventilated septic animals (P < 0.05). Sham animals similarly ventilated without PEEP maintained oxygenation, percent large aggregates and surfactant function. With the addition of PEEP, the deterioration in oxygenation was not observed in the septic animals and was associated with no alterations in the surfactant system. We conclude that animals with sepsis-induced lung injury are more susceptible to the harmful effects of mechanical ventilation, specifically lung collapseand reopening, and that alterations in alveolar surfactant may contribute to the development of lung dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:27:12